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Drug Tolerance in Biomembranes: A Spin Label Study of the Effects of Ethanol
Abstract
Ethanol in vitro increased the fluidity of spin-labeled membranes from normal mice. Membranes from mice that had been subjected to long-term ethanol treatment were relatively resistant to this fluidizing effect. The data suggest that the membranes themselves had adapted to the drug, a novel form of drug tolerance.
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Citations
Cited by
Effects of Alcohols on Micro-Organisms
Ingram, L. O., & Buttke, T. M. (1985) · Advances in Microbial Physiology · doi:10.1016/s0065-2911(08)60294-5 · Cited by 554
Under the Influence of Alcohol: The Effect of Ethanol and Methanol on Lipid Bilayers
Patra, M., Salonen, E., Terama, E., Vattulainen, I., Faller, R., Lee, B. W., Holopainen, J., & Karttunen, M. (2006) · Biophysical Journal · doi:10.1529/biophysj.105.062364 · Cited by 429
Phosphatidylethanol Formation via Transphosphatidylation by Rat Brain Synaptosomal Phospholipase D
Kobayashi, M., & Kanfer, J. N. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb05707.x · Cited by 340
Hepatic, Metabolic and Toxic Effects of Ethanol: 1991 Update
Lieber, C. S. (1991) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1991.tb00563.x · Cited by 279
Mechanism of ethanol induced hepatic injury
Lieber, C. S. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90032-w · Cited by 168
Metadata
- Authors
- Chin, J. H., & Goldstein, D. B.
- Venue
- Science
- Published
- 1977-05-06
- Volume
- 196
- Issue
- 4290
- Pages
- 684-685
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2084726236
- Cited by
- 514
- References
- 0
- FWCI
- 14.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chin, J. H., & Goldstein, D. B. (1977). Drug Tolerance in Biomembranes: A Spin Label Study of the Effects of Ethanol. Science. https://doi.org/10.1126/science.193186
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
