The DOI matches its Crossref record.
Pulmonary Surfactant Protein B (SP-B): Structure-Function Relationships
Abstract
SP-B is a protein in pulmonary surfactant that is, in greatest part, responsible for resistance to surface tension and prevention of collapse of pulmonary alveoli. Peptides of 21 residues, synthesized following the sequence of SP-B or resembling the hydrophobic and hydrophilic domains of SP-B (such as RLLLLRLLLLRLLLLRLLLLR, R, Arg, and L, Leu), enhanced the abilities of phospholipids to reduce surface tension both in vitro and in vivo. Intermittent positively charged residues were essential for this activity. The SP-B-like peptides were found by tryptophan fluorescence to partition within the phospholipid layer in contact with both polar head groups and acyl side chains. These data, together with findings that the SP-B-related peptides increase inter- and intramolecular order of the phospholipid layer, suggest that SP-B resists surface tension by increasing lateral stability of the phospholipid layer.
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Cited by
Genetic polymorphisms in sepsis
Dahmer, M. K., Randolph, A., Vitali, S., & Quasney, M. W. (2005) · Pediatric Critical Care Medicine · doi:10.1097/01.pcc.0000161970.44470.c7 · Cited by 101
Metadata
- Authors
- Cochrane, C. G., & Revak, S. D.
- Venue
- Science
- Published
- 1991-10-25
- Volume
- 254
- Issue
- 5031
- Pages
- 566-568
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2007603804
- Cited by
- 308
- References
- 0
- FWCI
- 12.78
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
