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Protein Hydration in Aqueous Solution
Abstract
High-resolution proton nuclear magnetic resonance studies of protein hydration in aqueous solution show that there are two qualitatively different types of hydration sites. A well-defined, small number of water molecules in the interior of the protein are in identical locations in the crystal structure and in solution, and their residence times are in the range from about 10 -2 to 10 -8 second. Hydration of the protein surface in solution is by water molecules with residence times in the subnanosecond range, even when they are located in hydration sites that contain well-ordered water in the x-ray structures of protein single crystals.
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Citations
Cited by
Water as an active constituent in cell biology
Ball, P. (2008) · Chemical Reviews · doi:10.1021/cr068037a · Cited by 2,177
Atomic-level characterization of the structural dynamics of proteins
Shaw, D. E., Maragakis, P., Lindorff-Larsen, K., Piana, S., Dror, R. O., Eastwood, M. P., Bank, J. A., Jumper, J. M., Salmon, J. K., Shan, Y., et al. (2010) · Science · doi:10.1126/science.1187409 · Cited by 1,923
Desiccation tolerance of prokaryotes
Potts, M. (1994) · Microbiological Reviews · doi:10.1128/mr.58.4.755-805.1994 · Cited by 1,382
Solution structure of p53 core domain: Structural basis for its instability
Cañadillas, J. M. P., Tidow, H., Freund, S. M. V., Rutherford, T. J., Ang, H. C., & Fersht, A. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510941103 · Cited by 174
Orientational disorder and entropy of water in protein cavities
Denisov, V. P., Venu, K., Peters, J., Hörlein, H. D., & Halle, B. (1997) · The Journal of Physical Chemistry B · doi:10.1021/jp9712213 · Cited by 108
Metadata
- Authors
- Otting, G., Liepinsh, E., & Wüthrich, K.
- Venue
- Science
- Published
- 1991-11-15
- Volume
- 254
- Issue
- 5034
- Pages
- 974-980
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2069298274
- Cited by
- 787
- References
- 0
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Otting, G., Liepinsh, E., & Wüthrich, K. (1991). Protein Hydration in Aqueous Solution. Science. https://doi.org/10.1126/science.1948083
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