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Protein Hydration in Aqueous Solution
Abstract
High-resolution proton nuclear magnetic resonance studies of protein hydration in aqueous solution show that there are two qualitatively different types of hydration sites. A well-defined, small number of water molecules in the interior of the protein are in identical locations in the crystal structure and in solution, and their residence times are in the range from about 10 -2 to 10 -8 second. Hydration of the protein surface in solution is by water molecules with residence times in the subnanosecond range, even when they are located in hydration sites that contain well-ordered water in the x-ray structures of protein single crystals.
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Citations
Cited by
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Ball, P. (2008) · Chemical Reviews · doi:10.1021/cr068037a · Cited by 2,177
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Shaw, D. E., Maragakis, P., Lindorff-Larsen, K., Piana, S., Dror, R. O., Eastwood, M. P., Bank, J. A., Jumper, J. M., Salmon, J. K., Shan, Y., et al. (2010) · Science · doi:10.1126/science.1187409 · Cited by 1,923
Desiccation tolerance of prokaryotes
Potts, M. (1994) · Microbiological Reviews · doi:10.1128/mr.58.4.755-805.1994 · Cited by 1,382
Solution structure of p53 core domain: Structural basis for its instability
Cañadillas, J. M. P., Tidow, H., Freund, S. M. V., Rutherford, T. J., Ang, H. C., & Fersht, A. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510941103 · Cited by 174
Orientational disorder and entropy of water in protein cavities
Denisov, V. P., Venu, K., Peters, J., Hörlein, H. D., & Halle, B. (1997) · The Journal of Physical Chemistry B · doi:10.1021/jp9712213 · Cited by 108
Saxena, K., Singh, P., Sahoo, P., Sahu, S., Ghosh, S., Ray, K., Fujita, D., & Bandyopadhyay, A. (2020) · Fractal and Fractional · doi:10.3390/fractalfract4020011 · Cited by 71
Assessing AF2’s ability to predict structural ensembles of proteins
Riccabona, J. R., Spoendlin, F. C., Fischer, A.-L. M., Loeffler, J. R., Quoika, P. K., Jenkins, T. P., Ferguson, J. A., Smorodina, E., Laustsen, A. H., Greiff, V., et al. (2024) · Structure · doi:10.1016/j.str.2024.09.001 · Cited by 17
Metadata
- Authors
- Otting, G., Liepinsh, E., & Wüthrich, K.
- Venue
- Science
- Published
- 1991-11-15
- Volume
- 254
- Issue
- 5034
- Pages
- 974-980
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2069298274
- Cited by
- 787
- References
- 0
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
