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A Homolog of the armadillo Protein in Drosophila (Plakoglobin) Associated with E-Cadherin
Abstract
Three cytoplasmic proteins, called catenins, bind to the cytoplasmic tail of the epithelial cell-cell adhesion molecule E-cadherin. The complementary DNA sequence was determined for the 92-kilodalton β catenin of Xenopus laevis . The sequence is homologous to mammalian plakoglobin, a protein of desmosomal and zonula adherens cell junctions, and to the plakoglobin homolog in Drosophila melanogaster , the product of the segment polarity gene armadillo . A monoclonal antibody to bovine plakoglobin recognizes the analogous β catenin in the Madin-Darby canine kidney (MDCK) cell line. Armadillo plakoglobin may link E-cadherin to the underlying actin cytoskeleton at cell-cell junctions; the E-cadherin-catenin protein complex may also participate in the transmission of developmental information.
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Cited by
Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
Wnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824
The many faces and functions of β‐catenin
Valenta, T., Hausmann, G., & Basler, K. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.150 · Cited by 1,598
Wnt signalling and its impact on development and cancer
Klaus, A., & Birchmeier, W. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2389 · Cited by 1,595
Metadata
- Authors
- McCrea, P. D., Turck, C. W., & Gumbiner, B.
- Venue
- Science
- Published
- 1991-11-29
- Volume
- 254
- Issue
- 5036
- Pages
- 1359-1361
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2087762539
- Cited by
- 623
- References
- 0
- FWCI
- 14.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Homolog of the armadillo Protein in Drosophila (Plakoglobin) Associated with E-Cadherin. https://app.cochat.ai/papers/10.1126/science.1962194
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- McCrea, P. D., Turck, C. W., & Gumbiner, B. (1991). A Homolog of the armadillo Protein in Drosophila (Plakoglobin) Associated with E-Cadherin. Science. https://doi.org/10.1126/science.1962194
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