The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Systemic Delivery of Human Growth Hormone by Injection of Genetically Engineered Myoblasts
Abstract
A recombinant gene encoding human growth hormone (hGH) was stably introduced into cultured myoblasts with a retroviral vector. After injection of genetically engineered myoblasts into mouse muscle, hGH could be detected in serum for 3 months. The fate of injected myoblasts was assessed by coinfecting the cells with two retroviral vectors, one encoding hGH and the other encoding β-galactosidase from Escherichia coli . These results provide evidence that myoblasts, which can fuse into preexisting multinucleated myofibers that are vascularized and innervated, may be advantageous as vehicles for systemic delivery of recombinant proteins.
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Cites
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
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Direct Gene Transfer into Mouse Muscle in Vivo
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Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA
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Effects of Human Growth Hormone in Men over 60 Years Old
Rudman, D., Feller, A. G., Nagraj, H. S., Gergans, G. A., Lalitha, P. Y., Goldberg, A. F., Schlenker, R. A., Cohn, L., Rudman, I. W., & Mattson, D. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007053230101 · Cited by 1,555
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Conversion of mdx myofibres from dystrophin-negative to -positive by injection of normal myoblasts
Partridge, T. A., Morgan, J. E., Coulton, G. R., Hoffman, E. P., & Kunkel, L. M. (1989) · Nature · doi:10.1038/337176a0 · Cited by 878
Danos, O., & Mulligan, R. C. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6460 · Cited by 875
Plasticity of the Differentiated State
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Self-citationSite-Specific Gene Expression in Vivo by Direct Gene Transfer into the Arterial Wall
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Human dystrophin expression in mdx mice after intramuscular injection of DNA constructs
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Cited by
Recombinant adeno-associated virus for muscle directed gene therapy
Fisher, K. J., Jooss, K., Alston, J., Yang, Y., Haecker, S. E., High, K., Pathak, R., Raper, S. E., & Wilson, J. M. (1997) · Nature Medicine · doi:10.1038/nm0397-306 · Cited by 654
The mitotic clock in skeletal muscle regeneration, disease and cell mediated gene therapy
Mouly, V., Aamiri, A., Bigot, A., Cooper, R. N., Di Donna, S., Furling, D., Gidaro, T., Jacquemin, V., Mamchaoui, K., Negroni, E., et al. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2005.01417.x · Cited by 106
Myoblast-mediated gene transfer to the joint
Day, C. S., Kasemkijwattana, C., Menetrey, J., Floyd, S. S., Booth, D., Moreland, M. S., Fu, F. H., & Huard, J. (1997) · Journal of Orthopaedic Research · doi:10.1002/jor.1100150616 · Cited by 66
Metadata
- Authors
- Dhawan, J., Pan, L. C., Pavlath, G. K., Travis, M. A., Lanctot, A. M., & Blau, H. M.
- Venue
- Science
- Published
- 1991-12-06
- Volume
- 254
- Issue
- 5037
- Pages
- 1509-1512
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2023506304
- Cited by
- 317
- References
- 32
- FWCI
- 16.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Systemic Delivery of Human Growth Hormone by Injection of Genetically Engineered Myoblasts. https://app.cochat.ai/papers/10.1126/science.1962213
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- Dhawan, J., Pan, L. C., Pavlath, G. K., Travis, M. A., Lanctot, A. M., & Blau, H. M. (1991). Systemic Delivery of Human Growth Hormone by Injection of Genetically Engineered Myoblasts. Science. https://doi.org/10.1126/science.1962213
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
