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Posttranslational Glutamylation of α-tubulin
Abstract
The high degree of tubulin heterogeneity in neurons is controlled mainly at the posttranslational level. Several variants of α-tubulin can be posttranslationally labeled after incubation of cells with [ 3 H]acetate or [ 3 H]glutamate. Peptides carrying the radioactive moiety were purified by high-performance liquid chromatography. Amino acid analysis, Edman degradation sequencing, and mass spectrometric analysis of these peptides led to the characterization of a posttranslational modification consisting of the successive addition of glutamyl units on the γ-carboxyl group of a glutamate residue (Glu 445 ). This modification, localized within a region of α-tubulin that is important in the interactions of tubulin with microtubule-associated proteins and calcium, could play a role in regulating microtubule dynamics.
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Vallee, R. B. (1982) · The Journal of cell biology · doi:10.1083/jcb.92.2.435 · Cited by 551
Cited by
UniProt: the universal protein knowledgebase
The UniProt Consortium (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw1099 · Cited by 4,436
The tubulin code and its role in controlling microtubule properties and functions
Janke, C., & Magiera, M. M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0214-3 · Cited by 956
Regulation of microtubule motors by tubulin isotypes and post-translational modifications
Sirajuddin, M., Rice, L. M., & Vale, R. D. (2014) · Nature Cell Biology · doi:10.1038/ncb2920 · Cited by 600
The production of poly-(γ-glutamic acid) from microorganisms and its various applications
Shih, I.-L., & Van, Y.-T. (2001) · Bioresource Technology · doi:10.1016/s0960-8524(01)00074-8 · Cited by 579
Verhey, K. J., & Gaertig, J. (2007) · Cell Cycle · doi:10.4161/cc.6.17.4633 · Cited by 558
Metadata
- Authors
- Eddé, B., Rossier, J., Le Caer, J.-P., Desbruyères, E., Gros, F., & Denoulet, P.
- Venue
- Science
- Published
- 1990-01-05
- Volume
- 247
- Issue
- 4938
- Pages
- 83-85
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982582935
- Cited by
- 555
- References
- 1
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Eddé, B., Rossier, J., Le Caer, J.-P., Desbruyères, E., Gros, F., & Denoulet, P. (1990). Posttranslational Glutamylation of α-tubulin. Science. https://doi.org/10.1126/science.1967194
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
