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Requirement for Cotolerogenic Gene Products in the Clonal Deletion of I-E Reactive T Cells
Abstract
T cells that express the T cell receptor V β 5.2 domain react with the class II major histocompatibility complex (MHC) molecule I-E, and V β 5.2 + T cells are deleted in mouse strains that express I-E glycoproteins. By examination of genetically defined recombinant inbred (RI) mouse strains, it was found that the deletion was dependent on the expression of I-E and one of a limited number of non-MHC gene products (cotolerogens). The gene encoding one of these cotolerogens maps to chromosome 12 and is linked to the endogenous provirus Mtv-9. These observations suggest that the I-E-mediated and minor lymphocyte-stimulating antigen (Mls)-mediated deletions of αβ T cells from the repertoire are similar; both require the expression of a class II MHC glycoprotein and a second non-MHC gene product.
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Cited by
Pfeffer, K., Matsuyama, T., Kündig, T. M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P. S., Krönke, M., & Mak, T. W. (1993) · Cell · doi:10.1016/0092-8674(93)90134-c · Cited by 1,677
Differential T Cell Costimulatory Requirements in CD28-Deficient Mice
Shahinian, A., Pfeffer, K., Lee, K. P., Kündig, T. M., Kishihara, K., Wakeham, A., Kawai, K., Ohashi, P. S., Thompson, C. B., & Mak, T. W. (1993) · Science · doi:10.1126/science.7688139 · Cited by 1,257
Development and Selection of T Cells: Facts and Puzzles
Kisielow, P., & Von Boehmer, H. (1995) · Advances in Immunology · doi:10.1016/s0065-2776(08)60620-3 · Cited by 444
Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice
Frankel, W. N., Rudy, C., Coffin, J. M., & Huber, B. T. (1991) · Nature · doi:10.1038/349526a0 · Cited by 306
Cainan, B. J., Szychowski, S., Ka-Ming Chan, F., Cado, D., & Winoto, A. (1995) · Immunity · doi:10.1016/1074-7613(95)90113-2 · Cited by 300
Metadata
- Authors
- Woodland, D., Happ, M. P., Bill, J., & Palmer, E.
- Venue
- Science
- Published
- 1990-02-23
- Volume
- 247
- Issue
- 4945
- Pages
- 964-967
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1990405032
- Cited by
- 192
- References
- 0
- FWCI
- 17.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Requirement for Cotolerogenic Gene Products in the Clonal Deletion of I-E Reactive T Cells. https://app.cochat.ai/papers/10.1126/science.1968289
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- Woodland, D., Happ, M. P., Bill, J., & Palmer, E. (1990). Requirement for Cotolerogenic Gene Products in the Clonal Deletion of I-E Reactive T Cells. Science. https://doi.org/10.1126/science.1968289
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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