The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance
Abstract
During development in the thymus, T cells are rendered tolerant to self antigens. It is now apparent that thymocytes bearing self-reactive T cell receptors can be tolerized by processes that result in physical elimination (clonal deletion) or functional inactivation (clonal anergy). As these mechanisms have important clinical implications for transplantation and autoimmunity, current investigations are focused on understanding the cellular and molecular interactions that generate these forms of tolerance.
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Citations
Cites
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T cell tolerance by clonal elimination in the thymus
Kappler, J. W., Roehm, N., & Marrack, P. (1987) · Cell · doi:10.1016/0092-8674(87)90568-x · Cited by 2,211
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A cell culture model for T lymphocyte clonal anergy
Schwartz, R. H. (1990) · Science · doi:10.1126/science.2113314 · Cited by 1,857
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Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
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Cited by
A cell culture model for T lymphocyte clonal anergy
Schwartz, R. H. (1990) · Science · doi:10.1126/science.2113314 · Cited by 1,857
Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand
Takahashi, T., Tanaka, M., Brannan, C. I., Jenkins, N. A., Copeland, N. G., Suda, T., & Nagata, S. (1994) · Cell · doi:10.1016/0092-8674(94)90375-1 · Cited by 1,528
Rapoport, M. J., Jaramillo, A., Zipris, D., Lazarus, A. H., Serreze, D. V., Leiter, E. H., Cyopick, P., Danska, J. S., & Delovitch, T. L. (1993) · The Journal of experimental medicine · doi:10.1084/jem.178.1.87 · Cited by 507
Steinbrink, K., Graulich, E., Kubsch, S., Knop, J., & Enk, A. H. (2002) · Blood · doi:10.1182/blood.v99.7.2468 · Cited by 448
Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)
Cooke, M. P., Abraham, K. M., Forbush, K. A., & Perimutter, R. M. (1991) · Cell · doi:10.1016/0092-8674(91)90162-r · Cited by 381
Metadata
- Authors
- Ramsdell, F., & Fowlkes, B. J.
- Venue
- Science
- Published
- 1990-06-15
- Volume
- 248
- Issue
- 4961
- Pages
- 1342-1348
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2019522474
- Cited by
- 366
- References
- 60
- FWCI
- 18.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ramsdell, F., & Fowlkes, B. J. (1990). Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance. Science. https://doi.org/10.1126/science.1972593
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
