The DOI matches its Crossref record.
Selective Destruction of Neurons by a Transmitter Agonist
Abstract
Microinjection of nanomole amounts of kainic acid, a heterocyclic analog of glutamate, into the cerebellums of adult hamsters and rats causes rapid degeneration of Purkinje, basket, stellate, and Golgi II cells, neurons that receive synaptic input from granule cells, whereas the granule cells themselves are spared. This selectivity is consistent with the evidence that glutamate is the granule cell transmitter and supports the hypothesis that kainic acid exerts its neurotoxic effects through glutamate receptors.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Choi, D. W. (1992) · Journal of Neurobiology · doi:10.1002/neu.480230915 · Cited by 2,314
Ito, M., Sakurai, M., & Tongroach, P. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014103 · Cited by 958
Foster, A. C., & Fagg, G. E. (1984) · Brain Research Reviews · doi:10.1016/0165-0173(84)90020-1 · Cited by 818
Cerebellar Control of the Vestibulo-Ocular Reflex--Around the Flocculus Hypothesis
Ito, M. (1982) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.05.030182.001423 · Cited by 657
Ben-Ari, Y., Tremblay, E., Riche, D., Ghilini, G., & Naquet, R. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90193-7 · Cited by 649
Metadata
- Authors
- Herndon, R. M., & Coyle, J. T.
- Venue
- Science
- Published
- 1977-10-07
- Volume
- 198
- Issue
- 4312
- Pages
- 71-72
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2022071328
- Cited by
- 196
- References
- 0
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Selective Destruction of Neurons by a Transmitter Agonist. https://app.cochat.ai/papers/10.1126/science.197604
- The paper
- Herndon, R. M., & Coyle, J. T. (1977). Selective Destruction of Neurons by a Transmitter Agonist. Science. https://doi.org/10.1126/science.197604
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
