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Cited by 2,314

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Excitotoxic cell death

Choi, Dennis W.·1992·Journal of Neurobiology

Abstract

Excitotoxicity refers to the ability of glutamate or related excitatory amino acids to mediate the death of central neurons under certain conditions, for example, after intense exposure. Such excitotoxic neuronal death may contribute to the pathogenesis of brain or spinal cord injury associated with several human disease states. Excitotoxicity has substantial cellular specificity and, in most cases, is mediated by glutamate receptors. On average, NMDA receptors activation may be able to trigger lethal injury more rapidly than AMPA or kainate receptor activation, perhaps reflecting a greater ability to induce calcium influx and subsequent cellular calcium overload. It is possible that excitotoxic death may share some mechanisms with other forms of neuronal death. © 1992 John Wiley & Sons, Inc.

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Metadata

Authors
Choi, D. W.
Venue
Journal of Neurobiology
Publisher
Wiley
Published
1992-11
Volume
23
Issue
9
Pages
1261-1276
ISSN
  • 0022-3034 (ISSN-L)
  • 1097-4695
OpenAlex
W2097293665
Cited by
2,314
References
5
FWCI
25.06
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Excitotoxic cell death. https://app.cochat.ai/papers/10.1002/neu.480230915
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Choi, D. W. (1992). Excitotoxic cell death. Journal of Neurobiology. https://doi.org/10.1002/neu.480230915

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.