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Reshaping the Cortical Motor Map by Unmasking Latent Intracortical Connections
Abstract
The primary motor cortex (MI) contains a map organized so that contralateral limb or facial movements are elicited by electrical stimulation within separate medial to lateral MI regions. Within hours of a peripheral nerve transection in adult rats, movements represented in neighboring MI areas are evoked from the cortical territory of the affected body part. One potential mechanism for reorganization is that adjacent cortical regions expand when preexisting lateral excitatory connections are unmasked by decreased intracortical inhibition. During pharmacological blockade of cortical inhibition in one part of the MI representation, movements of neighboring representations were evoked by stimulation in adjacent MI areas. These results suggest that intracortical connections form a substrate for reorganization of cortical maps and that inhibitory circuits are critically placed to maintain or readjust the form of cortical motor representations.
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Cited by
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Hochberg, L. R., Serruya, M. D., Friehs, G. M., Mukand, J. A., Saleh, M., Caplan, A. H., Branner, A., Chen, D., Penn, R. D., & Donoghue, J. P. (2006) · Nature · doi:10.1038/nature04970 · Cited by 3,295
Self-citationCORTICAL PLASTICITY: From Synapses to Maps
Buonomano, D. V., & Merzenich, M. M. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.149 · Cited by 2,083
The plastic human brain cortex
Pascual-Leone, A., Amedi, A., Fregni, F., & Merabet, L. B. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144216 · Cited by 1,929
Functional MRI evidence for adult motor cortex plasticity during motor skill learning
Kami, A., Meyer, G., Jezzard, P., Adams, M. M., Turner, R., & Ungerleider, L. G. (1995) · Nature · doi:10.1038/377155a0 · Cited by 1,883
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Stagg, C. J., & Nitsche, M. A. (2011) · The Neuroscientist · doi:10.1177/1073858410386614 · Cited by 1,719
Metadata
- Authors
- Jacobs, K. M., & Donoghue, J. P.
- Venue
- Science
- Published
- 1991-02-22
- Volume
- 251
- Issue
- 4996
- Pages
- 944-947
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1968131916
- Cited by
- 1,011
- References
- 0
- FWCI
- 15.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jacobs, K. M., & Donoghue, J. P. (1991). Reshaping the Cortical Motor Map by Unmasking Latent Intracortical Connections. Science. https://doi.org/10.1126/science.2000496
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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