The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Control of Embryonic Motoneuron Survival in Vivo by Ciliary Neurotrophic Factor
Abstract
During development of the nervous system, neurons in many regions are overproduced by proliferation, after which the excess cells are eliminated by cell death. The survival of only a proportion of neurons during normal development is thought to be regulated by the limited availability of neurotrophic agents. One such putative trophic agent is ciliary neurotrophic factor (CNTF), a polypeptide that promotes the survival of ciliary, sensory, and sympathetic neurons in vitro. In contrast to the results of in vitro studies, however, the daily treatment of chick embryos in vivo with purified human recombinant CNTF failed to rescue any of these cell populations from cell death, whereas CNTF did promote the in vivo survival of spinal motoneurons. Thus, CNTF may not act as a neurotrophic agent in vivo for those embryonic neurons (especially ciliary neurons) on which it acts in vitro. Rather, CNTF may be required for in vivo survival of motoneurons.
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Cites
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Regressive Events in Neurogenesis
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Cited by
Programmed Cell Death in Animal Development and Disease
Fuchs, Y., & Steller, H. (2011) · Cell · doi:10.1016/j.cell.2011.10.033 · Cited by 1,915
The cellular and molecular basis of peripheral nerve regeneration
Fu, S. Y., & Gordon, T. (1997) · Molecular Neurobiology · doi:10.1007/bf02740621 · Cited by 1,202
Schnell, L., Schneider, R., Kolbeck, R., Barde, Y.-A., & Schwab, M. E. (1994) · Nature · doi:10.1038/367170a0 · Cited by 909
Synaptic structure and development: The neuromuscular junction
Hall, Z. W., & Sanes, J. R. (1993) · Cell · doi:10.1016/s0092-8674(05)80031-5 · Cited by 834
Neurotrophic factors: from molecule to man
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Metadata
- Authors
- Oppenheim, R. W., Prevette, D., Qin-Wei, Y., Collins, F., & MacDonald, J.
- Venue
- Science
- Published
- 1991-03-29
- Volume
- 251
- Issue
- 5001
- Pages
- 1616-1618
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1985933922
- Cited by
- 446
- References
- 4
- FWCI
- 18.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Oppenheim, R. W., Prevette, D., Qin-Wei, Y., Collins, F., & MacDonald, J. (1991). Control of Embryonic Motoneuron Survival in Vivo by Ciliary Neurotrophic Factor. Science. https://doi.org/10.1126/science.2011743
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