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Reconciling the Magnitude of the Microscopic and Macroscopic Hydrophobic Effects
Abstract
The magnitude of the hydrophobic effect, as measured from the surface area dependence of the solubilities of hydrocarbons in water, is generally thought to be about 25 calories per mole per square angstrom (cal mol -1 Å -2 ). However, the surface tension at a hydrocarbon-water interface, which is a "macroscopic" measure of the hydrophobic effect, is ≈72 cal mol -1 Å -2 . In an attempt to reconcile these values, alkane solubility data have been reevaluated to account for solute-solvent size differences, leading to a revised "microscopic" hydrophobic effect of 47 cal mol -1 Å -2 . This value, when used in a simple geometric model for the curvature dependence of the hydrophobic effect, predicts a macroscopic alkane-water surface tension that is close to the macroscopic value.
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Citations
Cited by
Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK
Zhu, X., Zhao, X., Burkholder, W. F., Gragerov, A., Ogata, C. M., Gottesman, M. E., & Hendrickson, W. A. (1996) · Science · doi:10.1126/science.272.5268.1606 · Cited by 1,258
WATER MEDIATION IN PROTEIN FOLDING AND MOLECULAR RECOGNITION
Levy, Y., & Onuchic, J. N. (2006) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.35.040405.102134 · Cited by 1,048
A View of the Hydrophobic Effect
Southall, N. T., Dill, K. A., & Haymet, A. D. J. (2002) · The Journal of Physical Chemistry B · doi:10.1021/jp015514e · Cited by 913
Tsodikov, O. V., Record, M. T., & Sergeev, Y. V. (2002) · Journal of Computational Chemistry · doi:10.1002/jcc.10061 · Cited by 406
Modeling Water, the Hydrophobic Effect, and Ion Solvation
Dill, K. A., Truskett, T. M., Vlachy, V., & Hribar-Lee, B. (2005) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.34.040204.144517 · Cited by 401
Metadata
- Authors
- Sharp, K. A., Nicholls, A., Fine, R. F., & Honig, B.
- Venue
- Science
- Published
- 1991-04-05
- Volume
- 252
- Issue
- 5002
- Pages
- 106-109
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2039545730
- Cited by
- 512
- References
- 0
- FWCI
- 26.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Reconciling the Magnitude of the Microscopic and Macroscopic Hydrophobic Effects. https://app.cochat.ai/papers/10.1126/science.2011744
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- Sharp, K. A., Nicholls, A., Fine, R. F., & Honig, B. (1991). Reconciling the Magnitude of the Microscopic and Macroscopic Hydrophobic Effects. Science. https://doi.org/10.1126/science.2011744
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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