The DOI matches its Crossref record.
Biohybrid Artificial Pancreas: Long-Term Implantation Studies in Diabetic, Pancreatectomized Dogs
Abstract
Diabetic complications such as neuropathy, retinopathy, and renal and cardiovascular disease continue to pose major health risks for diabetic patients. Consequently, much effort has focused on approaches that could replace conventional insulin therapy and provide more precise regulation of blood glucose levels. The biohybrid perfused artificial pancreas was designed to incorporate islet tissue and a selectively permeable membrane that isolates this tissue from the immune system of the recipient. Biohybrid pancreas devices containing canine islet allografts were implanted in ten pancreatectomized dogs requiring 18 to 32 units of injected insulin daily. These implants resulted in good control of fasting glucose levels in six of these animals without further exogenous insulin for periods of up to 5 months.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Langer, R., & Vacanti, J. P. (1993) · Science · doi:10.1126/science.8493529 · Cited by 9,893
Implantable biohybrid artificial organs
Colton, C. (1995) · Cell Transplantation · doi:10.1016/0963-6897(95)00025-s · Cited by 586
Medical applications of membranes: Drug delivery, artificial organs and tissue engineering
Stamatialis, D. F., Papenburg, B. J., Gironés, M., Saiful, S., Bettahalli, S. N. M., Schmitmeier, S., & Wessling, M. (2008) · Journal of Membrane Science · doi:10.1016/j.memsci.2007.09.059 · Cited by 473
Scharp, D. W., & Marchetti, P. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.018 · Cited by 314
Hydrogels for Musculoskeletal Tissue Engineering
Varghese, S., & Elisseeff, J. H. (2006) · Advances in Polymer Science · doi:10.1007/12_072 · Cited by 173
Metadata
- Authors
- Sullivan, S. J., Maki, T., Borland, K. M., Mahoney, M. D., Solomon, B. A., Muller, T. E., Monaco, A. P., & Chick, W. L.
- Venue
- Science
- Published
- 1991-05-03
- Volume
- 252
- Issue
- 5006
- Pages
- 718-721
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2060655209
- Cited by
- 221
- References
- 0
- FWCI
- 19.76
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Biohybrid Artificial Pancreas: Long-Term Implantation Studies in Diabetic, Pancreatectomized Dogs. https://app.cochat.ai/papers/10.1126/science.2024124
- The paper
- Sullivan, S. J., Maki, T., Borland, K. M., Mahoney, M. D., Solomon, B. A., Muller, T. E., Monaco, A. P., & Chick, W. L. (1991). Biohybrid Artificial Pancreas: Long-Term Implantation Studies in Diabetic, Pancreatectomized Dogs. Science. https://doi.org/10.1126/science.2024124
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
