The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Implantable biohybrid artificial organs
Open accessAbstract
Biohybrid artificial organs encompass all devices which substitute for an organ or tissue function and incorporate both synthetic materials and living cells. This review concerns implantable immunoisolation devices in which the tissue is protected from immune rejection by enclosure within a semipermeable membrane. Two critical areas are discussed in detail: (i) Device design and performance as it relates to maintenance of cell viability and function. Attention is focussed on oxygen supply limitation and how it is affected by tissue density and the development of materials that induce neovascularization at the host tissue-membrane interface; and (ii) Protection from immune rejection. Our current knowledge of the mechanisms that may be operative in immune rejection in the presence of a semipermeable membrane barrier is limited. Nonetheless, recent studies shed light on the role played by membrane properties in preventing immune rejection, and many studies demonstrate substantial progress towards clinically useful implantable immunoisolation devices.
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Cites
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Cited by
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Polymers in cell encapsulation from an enveloped cell perspective
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Metadata
- Authors
- Colton, C.
- Venue
- Cell Transplantation
- Publisher
- Elsevier BV
- Published
- 1995-08
- Volume
- 4
- Issue
- 4
- Pages
- 415-436
- ISSN
- 0963-6897 (ISSN-L)
- OpenAlex
- W1976907471
- Cited by
- 586
- References
- 43
- FWCI
- 20.82
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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