The DOI matches its Crossref record.
Specific-Opiate-Induced Depression of Transmitter Release from Dorsal Root Ganglion Cells in Culture
Abstract
The opiate etorphine depresses monosynaptic excitatory postsynaptic potentials (EPSP's) elicited in spinal cord cells by activation of dorsal root ganglion cells in murine neuronal cell culture. The depression is reversed by naloxone. Statistical analysis of the synaptic responses reveals that the opiate reduces EPSP quantal content at this synapse without altering quantal size. Therefore, the opiate action is presynaptic and affects transmitter release rather than postsynaptic responsiveness.
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Citations
Cited by
Gibbins, I. L., Furness, J. B., & Costa, M. (1987) · Cell and Tissue Research · doi:10.1007/bf00218210 · Cited by 351
Tsunoo, A., Yoshii, M., & Narahashi, T. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9832 · Cited by 218
Metadata
- Authors
- Macdonald, R. L., & Nelson, P. G.
- Venue
- Science
- Published
- 1978-03-31
- Volume
- 199
- Issue
- 4336
- Pages
- 1449-1451
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2042049668
- Cited by
- 164
- References
- 0
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Specific-Opiate-Induced Depression of Transmitter Release from Dorsal Root Ganglion Cells in Culture. https://app.cochat.ai/papers/10.1126/science.204015
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- Macdonald, R. L., & Nelson, P. G. (1978). Specific-Opiate-Induced Depression of Transmitter Release from Dorsal Root Ganglion Cells in Culture. Science. https://doi.org/10.1126/science.204015
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
