The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
A corticosteroid Receptor in Neuronal Membranes
Abstract
Steroids may rapidly alter neuronal function and behavior through poorly characterized, direct actions on neuronal membranes. The membrane-bound receptors mediating these behavioral responses have not been identified. [3H]Corticosterone labels a population of specific, high-affinity recognition sites (dissociation constant = 0.51 nanomolar) in synaptic membranes from an amphibian brain. These binding sites were localized by receptor autoradiography in the neuropil, outside the regions of perikarya. The affinities of corticoids for this [3H]corticosterone binding site were linearly related to their potencies in rapidly suppressing male reproductive behavior. Thus, it appears that brain membranes contain a corticosteroid receptor that could participate in the regulation of behavior.
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“the discovery of adrenal steroid receptors that are G protein coupled in the amphibian brain (Orchinik et al., 1991)”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Orchinik et al., 1991
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Metadata
- Authors
- Orchinik, M., Murray, T. F., & Moore, F. L.
- Affiliations
- Oregon State University (US)
- ORCID
- Murray, Thomas F.
- Venue
- Science
- Published
- 1991-06-28
- Volume
- 252
- Issue
- 5014
- Pages
- 1848-1851
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061928804
- Cited by
- 523
- References
- 36
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 12 · 2015: 13 · 2014: 19 · 2013: 20 · 2012: 20
- FWCI
- 13.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- corticosteroid receptors, cell surface receptors, corticosterone binding, synaptic membranes, neuronal membrane, amphibian brain, male reproductive behavior, behavioral regulation, steroid binding affinity
- MeSH terms
- Amphibians, Animals, Autoradiography, Binding, Competitive, Brain, Cell Fractionation, Cell Membrane, Corticosterone, Kinetics, Male, Neurons, Receptors, Glucocorticoid, Sexual Behavior, Animal, Synaptosomes, Tritium
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