The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
A corticosteroid Receptor in Neuronal Membranes
Abstract
Steroids may rapidly alter neuronal function and behavior through poorly characterized, direct actions on neuronal membranes. The membrane-bound receptors mediating these behavioral responses have not been identified. [3H]Corticosterone labels a population of specific, high-affinity recognition sites (dissociation constant = 0.51 nanomolar) in synaptic membranes from an amphibian brain. These binding sites were localized by receptor autoradiography in the neuropil, outside the regions of perikarya. The affinities of corticoids for this [3H]corticosterone binding site were linearly related to their potencies in rapidly suppressing male reproductive behavior. Thus, it appears that brain membranes contain a corticosteroid receptor that could participate in the regulation of behavior.
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“the discovery of adrenal steroid receptors that are G protein coupled in the amphibian brain (Orchinik et al., 1991)”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Orchinik et al., 1991
Citations
Cites
Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
Majewska, M. D., Harrison, N. L., Schwartz, R. D., Barker, J. L., & Paul, S. M. (1986) · Science · doi:10.1126/science.2422758 · Cited by 2,225
STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS
Yamamoto, K. R. (1985) · Annual Review of Genetics · doi:10.1146/annurev.ge.19.120185.001233 · Cited by 1,850
Adrenal steroid receptors and actions in the nervous system
McEwen, B. S., de Kloet, E. R., & Rostène, W. H. (1986) · Physiological Reviews · doi:10.1152/physrev.1986.66.4.1121 · Cited by 1,238
Steroid Receptor Family: Structure and Functions
Carson, M. A., Schrader, W. T., & O’Malley, B. W. (1990) · Endocrine Reviews · doi:10.1210/edrv-11-2-201 · Cited by 813
Harrison, N. L., Majewska, M., Harrington, J. W., & Barker, J. L. (1987) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-5347(25)00332-5 · Cited by 611
de Kloet, E. R., & Reul, J. M. H. M. (1987) · Psychoneuroendocrinology · doi:10.1016/0306-4530(87)90040-0 · Cited by 595
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Neurosteroids act on recombinant human GABAA receptors
Puia, G., Santi, M., Vicini, S., Pritchett, D. B., Purdy, R. H., Paul, S. M., Seeburg, P. H., & Costa, E. (1990) · Neuron · doi:10.1016/0896-6273(90)90202-q · Cited by 514
The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor
Majewska, M. D., Demirgo¨ren, S., Spivak, C. E., & London, E. D. (1990) · Brain Research · doi:10.1016/0006-8993(90)90261-9 · Cited by 433
Biochemistry, Molecular Biology, and Physiology of the Glucocorticoid Receptor*
Gustafsson, J.-Α., Carlstedt‐Duke, J., Poellinger, L., Okret, S., Wikström, A., Brönnegård, M., Gillner, M., Dong, Y., Fuxé, K., Cintra, A., et al. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-2-185 · Cited by 402
Research works printed but not linked: 5
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Cited by
Sorted by citations
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429
The Corticosteroid Receptor Hypothesis of Depression
Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181
McEwen, B. S. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.071 · Cited by 1,864
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586
Metadata
- Authors
- Orchinik, M., Murray, T. F., & Moore, F. L.
- Affiliations
- Oregon State University (US)
- ORCID
- Murray, Thomas F.
- Venue
- Science
- Published
- 1991-06-28
- Volume
- 252
- Issue
- 5014
- Pages
- 1848-1851
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061928804
- Cited by
- 523
- References
- 36
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 12 · 2015: 13 · 2014: 19 · 2013: 20 · 2012: 20
- FWCI
- 13.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- corticosteroid receptors, cell surface receptors, corticosterone binding, synaptic membranes, neuronal membrane, amphibian brain, male reproductive behavior, behavioral regulation, steroid binding affinity
- MeSH terms
- Amphibians, Animals, Autoradiography, Binding, Competitive, Brain, Cell Fractionation, Cell Membrane, Corticosterone, Kinetics, Male, Neurons, Receptors, Glucocorticoid, Sexual Behavior, Animal, Synaptosomes, Tritium
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