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Cited by 342

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Polarity of the Blood-Brain Barrier: Neutral Amino Acid Transport into Isolated Brain Capillaries

Betz, A. Lorris, Goldstein, Gary W.·1978·Science
DOI 10.1126/science.211586
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Abstract

Capillary endothelial cells isolated from rat brain exhibit Na + -dependent uptake of the neutral amino acid analog α-(methylamino)isobutyric acid. Since studies in vivo demonstrate that this transport system is not present on the blood side of brain capillaries we conclude that Na + -dependent neutral amino acid transport is located on the brain side. Therefore, the luminal plasma membrane and the antiluminal plasma membrane appear to be functionally distinct. This polarity should permit brain capillary endothelial cells to actively regulate the internal milieu of the brain.

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Crossref · 10.1126/science.211586

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Metadata

Authors
Betz, A. L., & Goldstein, G. W.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1978-10-13
Volume
202
Issue
4364
Pages
225-227
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.211586
OpenAlex
W1994991276
Cited by
342
References
24
FWCI
8.25
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Polarity of the Blood-Brain Barrier: Neutral Amino Acid Transport into Isolated Brain Capillaries. https://app.cochat.ai/papers/10.1126/science.211586
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Betz, A. L., & Goldstein, G. W. (1978). Polarity of the Blood-Brain Barrier: Neutral Amino Acid Transport into Isolated Brain Capillaries. Science. https://doi.org/10.1126/science.211586

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.