The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Evidence that the Head of Kinesin Is Sufficient for Force Generation and Motility in Vitro
Abstract
Kinesin is a mechanochemical protein that converts the chemical energy in adenosine triphosphate into mechanical force for movement of cellular components along microtubules. The regions of the kinesin molecule responsible for generating movement were determined by studying the heavy chain of Drosophila kinesin, and its truncated forms, expressed in Escherichia coli . The results demonstrate that (i) kinesin heavy chain alone, without the light chains and other eukaryotic factors, is able to induce microtubule movement in vitro, and (ii) a fragment likely to contain only the kinesin head is also capable of inducing microtubule motility. Thus, the amino-terminal 450 amino acids of kinesin contain all the basic elements needed to convert chemical energy into mechanical force.
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Cites
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
VALE, R., REESE, T., & SHEETZ, M. (1985) · Cell · doi:10.1016/s0092-8674(85)80099-4 · Cited by 1,993
Hirokawa, N., Pfister, K. K., Yorifuji, H., Wagner, M. C., Brady, S. T., & Bloom, G. S. (1989) · Cell · doi:10.1016/0092-8674(89)90691-0 · Cited by 477
Kuznetsov, S. A., Vaisberg, Y. A., Rothwell, S. W., Murphy, D. B., & Gelfand, V. I. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31301-7 · Cited by 95
Cited by
Direct observation of kinesin stepping by optical trapping interferometry
Svoboda, K., Schmidt, C. F., Schnapp, B. J., & Block, S. M. (1993) · Nature · doi:10.1038/365721a0 · Cited by 1,910
Bead movement by single kinesin molecules studied with optical tweezers
Block, S. M., Goldstein, L. S. B., & Schnapp, B. J. (1990) · Nature · doi:10.1038/348348a0 · Cited by 1,038
Self-citationThe design plan of kinesin motors
Vale, R. D., & Fletterick, R. J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.745 · Cited by 474
Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly.
Hoyt, M. A., He, L., Loo, K. K., & Saunders, W. S. (1992) · The Journal of cell biology · doi:10.1083/jcb.118.1.109 · Cited by 391
Microtubule interaction site of the kinesin motor
Woehlke, G., Ruby, A. K., Hart, C. L., Ly, B., Hom-Booher, N., & Vale, R. D. (1997) · Cell · doi:10.1016/s0092-8674(00)80329-3 · Cited by 386
Metadata
- Authors
- Yang, J. T., Saxton, W. M., Stewart, R. J., Raff, E. C., & Goldstein, L. S. B.
- Venue
- Science
- Published
- 1990-07-06
- Volume
- 249
- Issue
- 4964
- Pages
- 42-47
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2014827729
- Cited by
- 225
- References
- 3
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, J. T., Saxton, W. M., Stewart, R. J., Raff, E. C., & Goldstein, L. S. B. (1990). Evidence that the Head of Kinesin Is Sufficient for Force Generation and Motility in Vitro. Science. https://doi.org/10.1126/science.2142332
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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