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Random Peptide Libraries: a Source of Specific Protein Binding Molecules
Abstract
Libraries of random peptide sequences were constructed and screened to identify peptides that specifically bind to proteins. In one of these about 2 × 10 7 different 15-residue peptide sequences were expressed on the surface of the coliphage M13. Each phage encoded a single random sequence and expressed it as a fusion complex with pIII, a minor coat protein present at five molecules per phage. Phage encoding nine different streptavidin-binding peptide sequences were isolated from this library. The core consensus sequence was His-Pro-Gln and binding of these phage to streptavidin was inhibited by biotin. This type of library makes it possible to identify peptides that bind to proteins (or other macromolecules) that have no previously known affinity for peptides.
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Cited by
Hoogenboom, H. R., Griffiths, A. D., Johnson, K. S., Chiswell, D. J., Hudson, P., & Winter, G. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.15.4133 · Cited by 1,020
Combinatorial synthesis — the design of compound libraries and their application to drug discovery
Terrett, N. K., Gardner, M., Gordon, D. W., Kobylecki, R. J., & Steele, J. (1995) · Tetrahedron · doi:10.1016/0040-4020(95)00467-m · Cited by 659
Schatz, P. J. (1993) · Nature Biotechnology · doi:10.1038/nbt1093-1138 · Cited by 580
Selection of peptides binding to the alpha 5 beta 1 integrin from phage display library.
Koivunen, E., Gay, D. A., & Ruoslahti, E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80715-7 · Cited by 344
Intersectin, a Novel Adaptor Protein with Two Eps15 Homology and Five Src Homology 3 Domains
Yamabhai, M., Hoffman, N. G., Hardison, N. L., McPherson, P. S., Castagnoli, L., Cesareni, G., & Kay, B. K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31401 · Cited by 256
Metadata
- Authors
- Devlin, J. J., Panganiban, L. C., & Devlin, P. E.
- Venue
- Science
- Published
- 1990-07-27
- Volume
- 249
- Issue
- 4967
- Pages
- 404-406
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1996427305
- Cited by
- 922
- References
- 0
- FWCI
- 22.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Devlin, J. J., Panganiban, L. C., & Devlin, P. E. (1990). Random Peptide Libraries: a Source of Specific Protein Binding Molecules. Science. https://doi.org/10.1126/science.2143033
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