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Cited by 959

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

Smith, Craig A., Davis, Terri, Anderson, Dirk, Solam, Lisabeth, Beckmann, M. Patricia, Jerzy, Rita, Dower, Steven K., Cosman, David, Goodwin, Raymond G.·1990·Science

Abstract

Tumor necrosis factor α and β (TNF-α and TNF-β) bind surface receptors on a variety of cell types to mediate a wide range of immunological responses, inflammatory reactions, and anti-tumor effects. A cDNA clone encoding an integral membrane protein of 461 amino acids was isolated from a human lung fibroblast library by direct expression screening with radiolabeled TNF-α. The encoded receptor was also able to bind TNF-β. The predicted cysteine-rich extracellular domain has extensive sequence similarity with five proteins, including nerve growth factor receptor and a transcriptionally active open reading frame from Shope fibroma virus, and thus defines a family of receptors.

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Crossref · 10.1126/science.2160731

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Metadata

Authors
Smith, C. A., Davis, T., Anderson, D., Solam, L., Beckmann, M. P., Jerzy, R., Dower, S. K., Cosman, D., & Goodwin, R. G.
Venue
Science
Published
1990-05-25
Volume
248
Issue
4958
Pages
1019-1023
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1971514924
Cited by
959
References
2
FWCI
43.09
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins. https://app.cochat.ai/papers/10.1126/science.2160731
The paper
Smith, C. A., Davis, T., Anderson, D., Solam, L., Beckmann, M. P., Jerzy, R., Dower, S. K., Cosman, D., & Goodwin, R. G. (1990). A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins. Science. https://doi.org/10.1126/science.2160731

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.