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Calcium Mobilization and Exocytosis After One Mechanical Stretch of Lung Epithelial Cells
Abstract
Deep inflation of the lung stimulates surfactant secretion by unknown mechanisms. The hypothesis that mechanical distension directly stimulates type II cells to secrete surfactant was tested by stretching type II cells cultured on silastic membranes. The intracellular Ca 2+concentration was measured in single cells, before and after stretching. A single stretch of alveolar type II cells caused a transient (less than 60 seconds) increase in cytosolic Ca 2+followed by a sustained (15 to 30 minutes) stimulation of surfactant secretion. Both Ca 2+mobilization and exocytosis exhibited dose-dependence to the magnitude of the stretch-stimulus. Thus, mechanical factors can trigger complex cellular events in nonneuron, nonmuscle cells and may be involved in regulating normal lung functions.
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Cited by
Functional significance of cell volume regulatory mechanisms
LANG, F., BUSCH, G. L., RITTER, M., VÖLKL, H., WALDEGGER, S., GULBINS, E., & HÄUSSINGER, D. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.247 · Cited by 1,891
Immunoregulatory functions of surfactant proteins
Wright, J. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1528 · Cited by 964
Burgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934
Alveolar epithelial type II cell: defender of the alveolus revisited
Fehrenbach, H. (2001) · Respiratory Research · doi:10.1186/rr36 · Cited by 757
Stretch induces cytokine release by alveolar epithelial cells in vitro
Vlahakis, N. E., Schroeder, M. A., Limper, A. H., & Hubmayr, R. D. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.1.l167 · Cited by 389
Metadata
- Authors
- Wirtz, H. R. W., & Dobbs, L. G.
- Venue
- Science
- Published
- 1990-11-30
- Volume
- 250
- Issue
- 4985
- Pages
- 1266-1269
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2004829388
- Cited by
- 511
- References
- 0
- FWCI
- 17.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wirtz, H. R. W., & Dobbs, L. G. (1990). Calcium Mobilization and Exocytosis After One Mechanical Stretch of Lung Epithelial Cells. Science. https://doi.org/10.1126/science.2173861
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