The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Spacing Differentiation in the Developing Drosophila Eye: a Fibrinogen-related Lateral Inhibitor Encoded by scabrous
Abstract
In the development of multicellular organisms a diversity of cell types differentiate at specific positions. Spacing patterns, in which an array of two or more cell types forms from a uniform field of cells, are a common feature of development. Identical precursor cells may adopt different fates because of competition and inhibition between them. Such a pattern in the developing Drosophila eye is the evenly spaced array of R8 cells, around which other cell types are subsequently recruited. Genetic studies suggest that the scabrous mutation disrupts a signal produced by R8 cells that inhibits other cells from also becoming R8 cells. The scabrous locus was cloned, and it appears to encode a secreted protein partly related to the β and γ chains of fibrinogen. It is proposed that the sca locus encodes a lateral inhibitor of R8 differentiation. The roles of the Drosophila EGF-receptor homologue (DER) and Notch genes in this process were also investigated.
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Cites
The chemical basis of morphogenesis
Turing, A. M. (1952) · Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences · doi:10.1098/rstb.1952.0012 · Cited by 11,733
Morel, Y., Bristow, J., Gitelman, S. E., & Miller, W. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.17.6582 · Cited by 158
Cited by
Regulation of development and differentiation by the extracellular matrix
Adams, J. C., & Watt, F. M. (1993) · Development · doi:10.1242/dev.117.4.1183 · Cited by 1,208
A Novel Human Serum Lectin with Collagen- and Fibrinogen-like Domains That Functions as an Opsonin
Matsushita, M., Endo, Y., Taira, S., Sato, Y., Fujita, T., Ichikawa, N., Nakata, M., & Mizuochi, T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.5.2448 · Cited by 329
Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B
Bristow, J., Tee, M., Gitelman, S., Mellon, S., & Miller, W. (1993) · The Journal of cell biology · doi:10.1083/jcb.122.1.265 · Cited by 302
The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate
(2018) · Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2018.02.002 · Cited by 286
Ma, C., & Moses, K. (1995) · Development · doi:10.1242/dev.121.8.2279 · Cited by 210
Metadata
- Authors
- Baker, N. E., Mlodzik, M., & Rubin, G. M.
- Venue
- Science
- Published
- 1990-12-07
- Volume
- 250
- Issue
- 4986
- Pages
- 1370-1377
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006679866
- Cited by
- 263
- References
- 2
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Spacing Differentiation in the Developing Drosophila Eye: a Fibrinogen-related Lateral Inhibitor Encoded by scabrous. https://app.cochat.ai/papers/10.1126/science.2175046
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- Baker, N. E., Mlodzik, M., & Rubin, G. M. (1990). Spacing Differentiation in the Developing Drosophila Eye: a Fibrinogen-related Lateral Inhibitor Encoded by scabrous. Science. https://doi.org/10.1126/science.2175046
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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