wingless and patched are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye
Abstract
In the developing Drosophila compound eye, a wave of pattern formation and cell-type determination sweeps across the presumptive eye epithelium. This 'morphogenetic furrow' coordinates the epithelial cells' division cycle, shape and gene expression to produce evenly spaced neural cell clusters that will eventually form the adult ommatidia. As these clusters develop, they rotate inwards to face the eye's equator and establish tissue polarity. We have found that wingless is strongly expressed in the dorsal margin of the presumptive eye field, ahead of the morphogenetic furrow. We have shown that inactivation of Wingless results in the induction of an ectopic furrow that proceeds ventrally from the dorsal margin. This ectopic furrow is normal in most respects, however the clusters formed by it fail to rotate, and we propose a two-vector model to account for normal rotation and tissue polarity in the retina. A second consequence of this inactivation of Wingless is that the dorsal head is largely deleted. We have also found that patched loss-of-function mosaic clones induce circular ectopic morphogenetic furrows (consistent with the observations of other workers with the hedgehog, and PKA genes). We use such patched induced furrows to test the two-vector model for cluster rotation and tissue polarity.
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In wild-type eye discs, Wg is expressed at the lateral margins anterior to the morphogenetic furrow.
“In wild-type eye discs, Wg is expressed at the lateral margins anterior to the morphogenetic furrow (Fig. 1I, I', quantified in K) (44).”
From A Tumour-Specific Molecular Network Promotes Tumour Growth in <i>Drosophila</i> by Enforcing a JNK-YKI Feedforward Loop (2023) · cites this paper as [44]
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- Authors
- Ma, C., & Moses, K.
- Affiliations
- University of Southern California (US)
- ORCID
- Moses, Kevin
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-08-01
- Volume
- 121
- Issue
- 8
- Pages
- 2279-2289
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1895850272
- Cited by
- 210
- References
- 70
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 10 · 2023: 5 · 2022: 4 · 2021: 1 · 2020: 8 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 4 · 2015: 5 · 2013: 5 · 2012: 4
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Keywords
- wingless, Patched, morphogenetic furrow, Drosophila compound eye, tissue polarity, Hedgehog signaling, PKA signaling, eye development
- MeSH terms
- Animals, Drosophila, Eye, Immunohistochemistry, Insect Hormones, Membrane Proteins, Microscopy, Electron, Scanning, Models, Biological, Morphogenesis, Proto-Oncogene Proteins, Receptors, Cell Surface, Retina, Gene Expression, Genes, Insect, In Situ Hybridization, Photoreceptor Cells, Invertebrate, Drosophila Proteins, Wnt1 Protein
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