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Targeting the E1 Replication Protein to the Papillomavirus Origin of Replication by Complex Formation with the E2 Transactivator
Abstract
The mechanism by which transcription factors stimulate DNA replication in eukaryotes is unknown. Bovine papillomavirus DNA synthesis requires the products of the viral E1 gene and the transcriptional activator protein encoded by the E2 gene. Experimental data showed that the 68-kilodalton (kD) E1 protein formed a complex with the 48-kD E2 transcription factor. This complex bound specifically to the viral origin of replication, which contains multiple binding sites for E2. Repressor proteins encoded by the E2 open reading frame failed to complex with E1 suggesting that the 162-amino acid region of E2 that participates in transactivation contained critical determinants for interaction with E1. The physical association between a replication protein and a transcription factor suggests that transcriptional activator proteins may function in targeting replication initiator proteins to their respective origins of replication.
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Cited by
Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity
Hebner, C. M., & Laimins, L. A. (2006) · Reviews in Medical Virology · doi:10.1002/rmv.488 · Cited by 401
A structure-informed atlas of human-virus interactions
Lasso, G., Mayer, S. V., Winkelmann, E. R., Chu, T., Elliot, O., Patino-Galindo, J. A., Park, K., Rabadan, R., Honig, B., & Shapira, S. D. (2019) · Cell · doi:10.1016/j.cell.2019.08.005 · Cited by 133
Lazarczyk, M., Cassonnet, P., Pons, C., Jacob, Y., & Favre, M. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00033-08 · Cited by 131
Mechanisms and strategies of papillomavirus replication
McBride, A. A. (2017) · Biological Chemistry · doi:10.1515/hsz-2017-0113 · Cited by 116
Metadata
- Authors
- Mohr, I. J., Clark, R., Sun, S., Androphy, E. J., MacPherson, P., & Botchan, M. R.
- Venue
- Science
- Published
- 1990-12-21
- Volume
- 250
- Issue
- 4988
- Pages
- 1694-1699
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1977393774
- Cited by
- 394
- References
- 0
- FWCI
- 23.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mohr, I. J., Clark, R., Sun, S., Androphy, E. J., MacPherson, P., & Botchan, M. R. (1990). Targeting the E1 Replication Protein to the Papillomavirus Origin of Replication by Complex Formation with the E2 Transactivator. Science. https://doi.org/10.1126/science.2176744
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