The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.
Human papillomaviruses: basic mechanisms of pathogenesis and oncogenicity
Abstract
Human papillomaviruses (HPVs) are small double‐stranded DNA viruses that infect the cutaneous and mucosal epithelium. Infection by specific HPV types has been linked to the development of cervical carcinoma. HPV infects epithelial cells that undergo terminal differentiation and so encode multiple mechanisms to override the normal regulation of differentiation to produce progeny virions. Two viral proteins, E6 and E7, alter cell cycle control and are the main arbitrators of HPV‐induced oncogenesis. Recent data suggest that E6 and E7 also play a major role in the inhibition of the host cell innate immune response to HPV. The E1 and E2 proteins, in combination with various cellular factors, mediate viral replication. In addition, E2 has been implicated in both viral and cellular transcriptional control. Despite decades of research, the function of other viral proteins still remains unclear. While prophylactic vaccines to block genital HPV infection will soon be available, the widespread nature of HPV infection requires greater understanding of both the HPV life cycle as well as the mechanisms underlying HPV‐induced carcinogenesis. Copyright © 2005 John Wiley & Sons, Ltd.
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Cites
Papillomaviruses and cancer: from basic studies to clinical application
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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
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HOW CELLS RESPOND TO INTERFERONS
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Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53
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A Controlled Trial of a Human Papillomavirus Type 16 Vaccine
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“In addition to extending the life of epithelial cells for production of viral progeny, this effect also influences HPV-induced carcinogenesis as overexpression of hTERT in conjunction with E7 expression has been shown to be sufficient to immortalise human primary keratinocytes [64].”
BackgroundEpidemiology of Genital Human Papillomavirus Infection
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Cited by
Establishment of human papillomavirus infection requires cell cycle progression
Pyeon, D., Pearce, S. M., Lank, S. M., Ahlquist, P., & Lambert, P. F. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000318 · Cited by 348
Lazarczyk, M., Cassonnet, P., Pons, C., Jacob, Y., & Favre, M. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00033-08 · Cited by 131
Morgan, I., DiNardo, L., & Windle, B. (2017) · Viruses · doi:10.3390/v9080208 · Cited by 65
Low- and high-risk human papillomavirus E7 proteins regulate p130 differently
Barrow-Laing, L., Chen, W., & Roman, A. (2010) · Virology · doi:10.1016/j.virol.2010.01.034 · Cited by 39
McLaughlin-Drubin, M., & Munger, K. (2013) · Viruses · doi:10.3390/v5051231 · Cited by 28
Metadata
- Authors
- Hebner, C. M., & Laimins, L. A.
- Venue
- Reviews in Medical Virology
- Publisher
- Wiley
- Published
- 2005-11-15
- Volume
- 16
- Issue
- 2
- Pages
- 83-97
- ISSN
- 1052-9276 (ISSN-L)
- 1099-1654
- OpenAlex
- W2100448174
- Cited by
- 401
- References
- 161
- FWCI
- 13.31
- Type
- journal article
- Language
- en
- Open access
- closed
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