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Calcium-Sensitive Inactivation in the Gating of Single Calcium Channels
Abstract
Voltage-activated calcium channels open and close, or gate, according to molecular transition rates that are regulated by transmembrane voltage and neurotransmitters. Here evidence for the control of gating by calcium was found in electrophysiological records of single, L-type calcium channels in heart cells. Conditional open probability analysis revealed that calcium entry during the opening of a single channel produces alterations in gating transition rates that evolve over the course of hundreds of milliseconds. Such alteration of calcium-channel gating by entry of a favored permeant ion provides a mechanism for the short-term modulation of single-ion channels.
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Citations
Cited by
Basic Mechanisms of Cardiac Impulse Propagation and Associated Arrhythmias
KLÉBER, A. G., & RUDY, Y. (2004) · Physiological Reviews · doi:10.1152/physrev.00025.2003 · Cited by 1,083
Calcium Channel Regulation and Presynaptic Plasticity
Catterall, W. A., & Few, A. P. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.005 · Cited by 647
Marrion, N. V., & Tavalin, S. J. (1998) · Nature · doi:10.1038/27674 · Cited by 543
L-Type Calcium Channels: The Low Down
Lipscombe, D., Helton, T. D., & Xu, W. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00486.2004 · Cited by 425
Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium
Legendre, P., Rosenmund, C., & Westbrook, G. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00674.1993 · Cited by 386
Metadata
- Authors
- Yue, D. T., Backx, P. H., & Imredy, J. P.
- Venue
- Science
- Published
- 1990-12-21
- Volume
- 250
- Issue
- 4988
- Pages
- 1735-1738
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2034042693
- Cited by
- 197
- References
- 0
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Calcium-Sensitive Inactivation in the Gating of Single Calcium Channels. https://app.cochat.ai/papers/10.1126/science.2176745
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- Yue, D. T., Backx, P. H., & Imredy, J. P. (1990). Calcium-Sensitive Inactivation in the Gating of Single Calcium Channels. Science. https://doi.org/10.1126/science.2176745
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
