The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Cell Proliferation in Carcinogenesis
Abstract
Chemicals that induce cancer at high doses in animal bioassays often fail to fit the traditional characterization of genotoxins. Many of these nongenotoxic compounds (such as sodium saccharin) have in common the property that they increase cell proliferation in the target organ. A biologically based, computerized description of carcinogenesis was used to show that the increase in cell proliferation can account for the carcinogenicity of nongenotoxic compounds. The carcinogenic dose-response relationship for genotoxic chemicals (such as 2-acetylaminofluorene) was also due in part to increased cell proliferation. Mechanistic information is required for determination of the existence of a threshold for the proliferative (and carcinogenic) response of nongenotoxic chemicals and the estimation of risk for human exposure.
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Cites
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Some Biological Aspects of Skin Carcinogenesis*
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Cited by
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Arsenic Exposure and Toxicology: A Historical Perspective
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Metadata
- Authors
- Cohen, S. M., & Ellwein, L. B.
- Venue
- Science
- Published
- 1990-08-31
- Volume
- 249
- Issue
- 4972
- Pages
- 1007-1011
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2034602546
- Cited by
- 1,050
- References
- 25
- FWCI
- 43.17
- Type
- journal article
- Language
- en
- Open access
- closed
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
