The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mutations Affecting Tea Blockade and Ion Permeation in Voltage-activated K + Channels
Abstract
Voltage-dependent ion channels are responsible for electrical signaling in neurons and other cells. The main classes of voltage-dependent channels (sodium-, calcium-, and potassium-selective channels) have closely related molecular structures. For one member of this superfamily, the transiently voltage-activated Shaker H4 potassium channel, specific amino acid residues have now been identified that affect channel blockade by the small ion tetraethylammonium, as well as the conduction of ions through the pore. Furthermore, variation at one of these amino acid positions among naturally occurring potassium channels may account for most of their differences in sensitivity to tetraethylammonium.
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Citations
Cites
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Cited by
Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs
Liman, E. R., Tytgat, J., & Hess, P. (1992) · Neuron · doi:10.1016/0896-6273(92)90239-a · Cited by 1,084
Calcium channel characteristics conferred on the sodium channel by single mutations
Heinemann, S. H., Terlau, H., Stühmer, W., Imoto, K., & Numa, S. (1992) · Nature · doi:10.1038/356441a0 · Cited by 784
Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors
Zhou, M., Morais-Cabral, J. H., Mann, S., & MacKinnon, R. (2001) · Nature · doi:10.1038/35079500 · Cited by 560
Self-citationThe aromatic binding site for tetraethylammonium ion on potassium channels
Heginbotham, L., & MacKinnon, R. (1992) · Neuron · doi:10.1016/0896-6273(92)90276-j · Cited by 451
Self-citationModulation of K+ current by frequency and external [K+]: A tale of two inactivation mechanisms
Baukrowitz, T., & Yellen, G. (1995) · Neuron · doi:10.1016/0896-6273(95)90185-x · Cited by 373
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Metadata
- Authors
- MacKinnon, R., & Yellen, G.
- Venue
- Science
- Published
- 1990-10-12
- Volume
- 250
- Issue
- 4978
- Pages
- 276-279
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2025884619
- Cited by
- 563
- References
- 1
- FWCI
- 16.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- MacKinnon, R., & Yellen, G. (1990). Mutations Affecting Tea Blockade and Ion Permeation in Voltage-activated K + Channels. Science. https://doi.org/10.1126/science.2218530
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
