The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Modulation of K+ current by frequency and external [K+]: A tale of two inactivation mechanisms
Open accessAbstract
Voltage-activated K+ currents and their inactivation properties are important for controlling frequency-dependent signaling in neurons and other excitable cells. Two distinct molecular mechanisms for K+ channel inactivation have been described: N-type, which involves rapid occlusion of the open channel by an intracellular tethered blocker, and C-type, which involves a slower change at the extracellular mouth of the pore. We find that frequency-dependent cumulative inactivation of Shaker channels is very sensitive to changes of extracellular [K+] in the physiological range, with much more inactivation at low [K+]out, and that it results from the interaction of N- and C-type inactivation. N-type inactivation enhances C-type inactivation by two mechanisms. First, it inhibits outward K+ flux, which normally fills an external ion site and thus prevents C-type inactivation. Second, it keeps the channel's activation gate open even after repolarization, allowing C-type inactivation to occur for a prolonged period.
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Cites
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Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation
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Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit
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Cited by
Molecular driving forces determining potassium channel slow inactivation
Cordero-Morales, J. F., Jogini, V., Lewis, A., Vásquez, V., Cortes, D. M., Roux, B., & Perozo, E. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1309 · Cited by 236
Expanded Functional Diversity of Shaker K+ Channels in Cnidarians Is Driven by Gene Expansion
Jegla, T., Marlow, H. Q., Chen, B., Simmons, D. K., Jacobo, S. M., & Martindale, M. Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051366 · Cited by 35
Metadata
- Authors
- Baukrowitz, T., & Yellen, G.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1995-10
- Volume
- 15
- Issue
- 4
- Pages
- 951-960
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2082585200
- Cited by
- 373
- References
- 29
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Baukrowitz, T., & Yellen, G. (1995). Modulation of K+ current by frequency and external [K+]: A tale of two inactivation mechanisms. Neuron. https://doi.org/10.1016/0896-6273(95)90185-x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
