The DOI matches its Crossref record.
Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA
Abstract
Lyme borreliosis is a tick-borne illness caused by Borrelia burgdorferi . The gene for outer surface protein A (OspA) from B. burgdorferi strain N40 was cloned into an expression vector and expressed in Escherichia coli . C3H/HeJ mice actively immunized with live transformed E. coli or purified recombinant OspA protein produced antibodies to OspA and were protected from challenge with several strains of B. burgdorferi . Recombinant OspA is a candidate for a vaccine for Lyme borreliosis.
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Citations
Cited by
Plotkin, S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400472111 · Cited by 642
Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks
Ohnishi, J., Piesman, J., & de Silva, A. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.670 · Cited by 317
Recombinant OspA protects dogs against infection and disease caused by Borrelia burgdorferi
Chang, Y. F., Appel, M. J., Jacobson, R. H., Shin, S. J., Harpending, P., Straubinger, R., Patrican, L. A., Mohammed, H., & Summers, B. A. (1995) · Infection and Immunity · doi:10.1128/iai.63.9.3543-3549.1995 · Cited by 76
Protection against tick-transmitted Lyme disease in dogs vaccinated with a multiantigenic vaccine
Straubinger, R. K., Dharma Rao, T., Davidson, E., Summers, B. A., Jacobson, R. H., & Frey, A. B. (2001) · Vaccine · doi:10.1016/s0264-410x(01)00251-1 · Cited by 23
Safety, efficacy and immunogenicity of a recombinant Osp subunit canine Lyme disease vaccine
Ma, J., Hine, P. M., Clough, E. R., Fish, D., Coughlin, R. T., Beltz, G. A., & Shew, M. G. (1996) · Vaccine · doi:10.1016/s0264-410x(96)00045-x · Cited by 21
Metadata
- Authors
- Fikrig, E., Barthold, S. W., Kantor, F. S., & Flavell, R. A.
- Venue
- Science
- Published
- 1990-10-26
- Volume
- 250
- Issue
- 4980
- Pages
- 553-556
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2024734793
- Cited by
- 488
- References
- 0
- FWCI
- 32.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA. https://app.cochat.ai/papers/10.1126/science.2237407
- The paper
- Fikrig, E., Barthold, S. W., Kantor, F. S., & Flavell, R. A. (1990). Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA. Science. https://doi.org/10.1126/science.2237407
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
