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Regional Variation of Extracellular Space in the Hippocampus
Abstract
The factors responsible for the unusual susceptibility of the hippocampus to seizures and ischemic cell damage are not well understood. The CA1 pyramidal subfield of the hippocampus is particularly vulnerable to seizure activity and damage after ischemia. The possibility was examined that regional differences exist in extracellular volume, which might influence neuronal excitability and response to injury in the hippocampus. CA1 stratum pyramidale exhibited an exceptionally low extracellular volume fraction (EVF) of 0.12, whereas the EVFs of CA3 and dentate were considerably higher—0.18 and 0.15, respectively. The EVF of CA1 stratum pyramidale was reversibly reduced by 30 percent when the extracellular potassium concentration was raised from 3.5 to 8.5 mM, a procedure that induced spontaneous electrographic seizures in CA1. Thus there are regional variations in the properties of the extracellular space in the hippocampus that might underlie the propensity of the CA1 region to develop seizures and to suffer damage after ischemia.
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Norepinephrine triggers rapid changes in neural activity, which in turn can modulate the volume of the interstitial space.
“NE triggers rapid changes in neural activity (27, 28), which in turn can modulate the volume of the interstitial space volume (29).”
From Sleep Drives Metabolite Clearance from the Adult Brain (2013) · cites this paper as [29]
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Metadata
- Authors
- McBain, C. J., Traynelis, S. F., & Dingledine, R.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- Science
- Published
- 1990-08-10
- Volume
- 249
- Issue
- 4969
- Pages
- 674-677
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1975934006
- Cited by
- 270
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 9 · 2014: 4 · 2013: 5 · 2012: 9
- FWCI
- 10.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (P01NS017771)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- extracellular space, hippocampus, extracellular volume fraction, extracellular potassium, neuronal excitability, regional variation, CA3, dentate gyrus
- MeSH terms
- Quaternary Ammonium Compounds, Animals, Diffusion, Extracellular Space, Hippocampus, Iontophoresis, Organ Specificity, Potassium, Pyramidal Tracts, Rats, Inbred Strains, Seizures, Rats, In Vitro Techniques
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