The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Endothelin: A Novel Peptide in the Posterior Pituitary System
Abstract
Endothelin (ET), originally characterized as a 21-residue vasoconstrictor peptide from endothelial cells, is present in the porcine spinal cord and may act as a neuropeptide. Endothelin-like immunoreactivity has now been demonstrated by immunohistochemistry in the paraventricular and supraoptic nuclear neurons and their terminals in the posterior pituitary of the pig and the rat. The presence of ET in the porcine hypothalamus was confirmed by reversed-phase high-pressure liquid chromatography and radioimmunoassay. Moreover, in situ hybridization demonstrated ET messenger RNA in porcine paraventricular nuclear neurons. Endothelin-like immunoreactive products in the posterior pituitary of the rat were depleted by water deprivation, suggesting a release of ET under physiological conditions. These findings indicate that ET is synthesized in the posterior pituitary system and may be involved in neurosecretory functions.
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Citations
Cites
Opiate inhibition of peptide release from the neurohumoral terminals of hypothalamic neurones
Clarke, G., Wood, P., Merrick, L., & Lincoln, D. W. (1979) · Nature · doi:10.1038/282746a0 · Cited by 219
Cited by
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
Endothelin System: The Double-Edged Sword in Health and Disease
Kedzierski, R. M., & Yanagisawa, M. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.851 · Cited by 745
Self-citationNeuroendocrine Control of Body Fluid Metabolism
ANTUNES-RODRIGUES, J., DE CASTRO, M., ELIAS, L. L. K., VALENÇA, M. M., & McCANN, S. M. (2004) · Physiological Reviews · doi:10.1152/physrev.00017.2003 · Cited by 468
Herbert, J. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90033-o · Cited by 98
Metadata
- Authors
- Yoshizawa, T., Shinmi, O., Giaid, A., Yanagisawa, M., Gibson, S. J., Kimura, S., Uchiyama, Y., Polak, J. M., Masaki, T., & Kanazawa, I.
- Venue
- Science
- Published
- 1990-01-26
- Volume
- 247
- Issue
- 4941
- Pages
- 462-464
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2055679500
- Cited by
- 311
- References
- 1
- FWCI
- 19.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yoshizawa, T., Shinmi, O., Giaid, A., Yanagisawa, M., Gibson, S. J., Kimura, S., Uchiyama, Y., Polak, J. M., Masaki, T., & Kanazawa, I. (1990). Endothelin: A Novel Peptide in the Posterior Pituitary System. Science. https://doi.org/10.1126/science.2405487
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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