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Angiogenesis Induced by Degradation Products of Hyaluronic Acid
Abstract
Partial degradation products of sodium hyaluronate produced by the action of testicular hyaluronidase induced an angiogenic response (formation of new blood vessels) on the chick chlorioallantoic membrane. Neither macromolecular hyaluronate nor exhaustively digested material had any angiogenic potential. Fractionation of the digestion products established that the activity was restricted to hyaluronate fragments between 4 and 25 disaccharides in length.
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Cited by
CD44: From adhesion molecules to signalling regulators
Ponta, H., Sherman, L., & Herrlich, P. A. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1004 · Cited by 2,386
Hyaluronan: from extracellular glue to pericellular cue
Toole, B. P. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1391 · Cited by 2,125
Hyaluronan as an Immune Regulator in Human Diseases
Jiang, D., Liang, J., & Noble, P. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00052.2009 · Cited by 1,060
Hyaluronic acid: A key molecule in skin aging
Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012) · Dermato-Endocrinology · doi:10.4161/derm.21923 · Cited by 1,031
Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties
Itano, N., Sawai, T., Yoshida, M., Lenas, P., Yamada, Y., Imagawa, M., Shinomura, T., Hamaguchi, M., Yoshida, Y., Ohnuki, Y., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.25085 · Cited by 901
Metadata
- Authors
- West, D. C., Hampson, I. N., Arnold, F., & Kumar, S.
- Venue
- Science
- Published
- 1985-06-14
- Volume
- 228
- Issue
- 4705
- Pages
- 1324-1326
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061095488
- Cited by
- 1,143
- References
- 0
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- West, D. C., Hampson, I. N., Arnold, F., & Kumar, S. (1985). Angiogenesis Induced by Degradation Products of Hyaluronic Acid. Science. https://doi.org/10.1126/science.2408340
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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