The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Rationale for Development of a Synthetic Vaccine Against Plasmodium falciparum Malaria
Abstract
Protective immunity against malaria can be obtained by vaccination with irradiated sporozoites. The protective antigens known as circumsporozoite (CS) proteins, are polypeptides that cover the surface membrane of the parasite. The CS proteins contain species-specific immunodominant epitopes formed by tandem repeated sequences of amino acids. Here it is shown that the dominant epitope of Plasmodium falciparum is contained in the synthetic dodecapeptide Asn-Ala-Asn-Pro-Asn-Ala-Asn-Pro-Asn-Ala-Asn-Pro or (NANP) 3 . Monoclonal antibodies and most or all polyclonal human antibodies to the sporozoites react with (NANP) 3 , and polyclonal antibodies raised against the synthetic peptide (NANP) 3 react with the surface of the parasite and neutralize its infectivity. Since (NANP) 3 repeats are present in CS proteins of P. falciparum from many parts of the world, this epitope is a logical target for vaccine development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Priming for and induction of anti-poliovirus neutralizing antibodies by synthetic peptides
Emini, E. A., Jameson, B. A., & Wimmer, E. (1983) · Nature · doi:10.1038/304699a0 · Cited by 237
Cited by
Weiss, W. R., Sedegah, M., Beaudoin, R. L., Miller, L. H., & Good, M. F. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.2.573 · Cited by 489
Mucosal leishmaniasis (“spundia” Escomel, 1911)
Marsden, P. D. (1986) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(86)90243-9 · Cited by 360
Cerami, C., Frevert, U., Sinnis, P., Takacs, B., Clavijo, P., Santos, M. J., & Nussenzweig, V. (1992) · Cell · doi:10.1016/0092-8674(92)90251-7 · Cited by 356
Self-citationTam, J. P., Clavijo, P., Lu, Y. A., Nussenzweig, V, Nussenzweig, R., & Zavala, F. (1990) · The Journal of experimental medicine · doi:10.1084/jem.171.1.299 · Cited by 320
Self-citationKisalu, N. K., Idris, A. H., Weidle, C., Flores-Garcia, Y., Flynn, B. J., Sack, B. K., Murphy, S., Schön, A., Freire, E., Francica, J. R., et al. (2018) · Nature Medicine · doi:10.1038/nm.4512 · Cited by 293
Self-citation
Metadata
- Authors
- Zavala, F., Tam, J. P., Hollingdale, M. R., Cochrane, A. H., Quakyi, I., Nussenzweig, R. S., & Nussenzweig, V.
- Venue
- Science
- Published
- 1985-06-21
- Volume
- 228
- Issue
- 4706
- Pages
- 1436-1440
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1992999474
- Cited by
- 367
- References
- 1
- FWCI
- 56.02
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Rationale for Development of a Synthetic Vaccine Against Plasmodium falciparum Malaria. https://app.cochat.ai/papers/10.1126/science.2409595
- The paper
- Zavala, F., Tam, J. P., Hollingdale, M. R., Cochrane, A. H., Quakyi, I., Nussenzweig, R. S., & Nussenzweig, V. (1985). Rationale for Development of a Synthetic Vaccine Against Plasmodium falciparum Malaria. Science. https://doi.org/10.1126/science.2409595
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
