The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Incorporation of T and B epitopes of the circumsporozoite protein in a chemically defined synthetic vaccine against malaria.
Open accessAbstract
We show here an effective and novel approach to engineer peptide-based vaccines using a chemically defined system, known as multiple peptide antigen systems (MAPs), to protect an inbred mouse strain from infection against rodent malaria. 10 mono- and di-epitope MAP models containing different arrangements and stoichiometry of functional B and/or T helper cell epitopes from the circumsporozoite protein of Plasmodium berghei were used to immunize A/J mice. While these mice did not respond to the mono-epitope MAP bearing only the B or T epitope, very high titers of antibody and protective immunity against sporozoite challenge were elicited by di-epitope MAPs, particularly those with the B and T epitopes in tandem and present in equimolar amounts. These results, obtained in a well-defined rodent malaria model, indicate that MAPs may overcome some of the difficulties in the development of synthetic vaccines, not only for malaria but also for other infectious diseases.
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Cites
Tam, J. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.15.5409 · Cited by 1,251
Self-citationMerrifield, B. (1986) · Science · doi:10.1126/science.3961484 · Cited by 1,005
γ Interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites
Schofield, L., Villaquiran, J., Ferreira, A., Schellekens, H., Nussenzweig, R., & Nussenzweig, V. (1987) · Nature · doi:10.1038/330664a0 · Cited by 713
Self-citationRomero, P., Maryanski, J. L., Corradin, G., Nussenzweig, R. S., Nussenzweig, V., & Zavala, F. (1989) · Nature · doi:10.1038/341323a0 · Cited by 505
Self-citationHerrington, D. A., Clyde, D. F., Losonsky, G., Cortesia, M., Murphy, J. R., Davis, J., Baqar, S., Felix, A. M., Heimer, E. P., Gillessen, D., et al. (1987) · Nature · doi:10.1038/328257a0 · Cited by 502
Self-citationWeiss, W. R., Sedegah, M., Beaudoin, R. L., Miller, L. H., & Good, M. F. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.2.573 · Cited by 489
Posnett, D. N., McGrath, H., & Tam, J. P. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77935-6 · Cited by 464
Self-citationSAFETY AND EFFICACY OF A RECOMBINANT DNA PLASMODIUM FALCIPARUM SPOROZOITE VACCINE
Ripley Ballou, W., Hoffman, S. L., Sherwood, J. A., Hollingdale, M. R., Neva, F. A., Hockmeyer, W. T., Gordon, D. M., Schneider, I., Wirtz, R. A., Young, J. F., et al. (1987) · The Lancet · doi:10.1016/s0140-6736(87)90540-x · Cited by 427
Rationale for Development of a Synthetic Vaccine Against Plasmodium falciparum Malaria
Zavala, F., Tam, J. P., Hollingdale, M. R., Cochrane, A. H., Quakyi, I., Nussenzweig, R. S., & Nussenzweig, V. (1985) · Science · doi:10.1126/science.2409595 · Cited by 367
Self-citationRationale for the Development of an Engineered Sporozoite Malaria Vaccine
Nussenzweig, V., & Nussenzweig, R. S. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60695-1 · Cited by 295
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Cited by
Black, M., Trent, A., Tirrell, M., & Olive, C. (2010) · Expert Review of Vaccines · doi:10.1586/erv.09.160 · Cited by 203
Metadata
- Authors
- Tam, J. P., Clavijo, P., Lu, Y. A., Nussenzweig, V, Nussenzweig, R., & Zavala, F.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1990-01-01
- Volume
- 171
- Issue
- 1
- Pages
- 299-306
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2111622853
- Cited by
- 320
- References
- 14
- FWCI
- 21.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tam, J. P., Clavijo, P., Lu, Y. A., Nussenzweig, V, Nussenzweig, R., & Zavala, F. (1990). Incorporation of T and B epitopes of the circumsporozoite protein in a chemically defined synthetic vaccine against malaria. The Journal of experimental medicine. https://doi.org/10.1084/jem.171.1.299
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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