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Prostacyclin Synthesis Induced in Vascular Cells by Interleukin-1
Abstract
Supernatants from cultures of human monocytes that had been stimulated with endotoxin or silica induced the synthesis of prostacyclin in endothelial and smooth muscle cells. The lymphokine mediating these effects on the cells of the blood vessel wall was identified as interleukin-1; interferons and interleukin-2 were inactive. Interleukin-1-induced prostacyclin synthesis represents a new aspect of the interaction between the immune system (as well as other tissues) and the vessel wall and may serve as a basis for the development of new strategies in antithrombotic therapy.
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Citations
Cited by
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
Human monocyte/macrophage activation and interleukin 1 generation by biomedical polymers
Miller, K. M., & Anderson, J. M. (1988) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820220805 · Cited by 156
Vascular transcellular signaling.
Marcus, A. J., & Hajjar, D. P. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)35344-x · Cited by 114
Immune Aspects of Wound Repair
Barbul, A. (1990) · Clinics in Plastic Surgery · doi:10.1016/s0094-1298(20)30618-0 · Cited by 111
Koumantakis, E., Matalliotakis, I., Neonaki, M., Froudarakis, G., & Georgoulias, V. (1994) · Archives of Gynecology and Obstetrics · doi:10.1007/bf02390936 · Cited by 65
Metadata
- Authors
- Rossi, V., Breviario, F., Ghezzi, P., Dejana, E., & Mantovani, A.
- Venue
- Science
- Published
- 1985-07-12
- Volume
- 229
- Issue
- 4709
- Pages
- 174-176
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2062604592
- Cited by
- 360
- References
- 0
- FWCI
- 33.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rossi, V., Breviario, F., Ghezzi, P., Dejana, E., & Mantovani, A. (1985). Prostacyclin Synthesis Induced in Vascular Cells by Interleukin-1. Science. https://doi.org/10.1126/science.2409598
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