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Characterization of Highly Immunogenic p66/p51 as the Reverse Transcriptase of HTLV-III/LAV
Abstract
Approximately 80 percent of all human sera that react with antigens of HTLV-III, the etiologic agent of the acquired immune deficiency syndrome (AIDS), recognize protein bands at 66 and 51 kilodaltons. A mouse hybridoma was produced that was specific to these proteins. Repeated cloning of the hybridoma did not separate the two reactivities. The p66/p51 was purified from HTLV-III lysates by immunoaffinity chromatography and subjected to NH2-terminal Edman degradation. Single amino acid residues were obtained in 17 successive degradation cycles. The sequence determined was a perfect translation of the nucleotide sequence of a portion of the HTLV-III pol gene. The purified p66/51 had reverse transcriptase activity and the monoclonal immunoglobulin G specifically removed the enzyme activity from crude viral extract as well as purified enzyme.
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Cited by
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor
Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A., & Steitz, T. A. (1992) · Science · doi:10.1126/science.1377403 · Cited by 1,914
Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase
Davies, J. F., Hostomska, Z., Hostomsky, Z., Jordan, S. R., & Matthews, D. A. (1991) · Science · doi:10.1126/science.1707186 · Cited by 570
Shirasaka, T., Kavlick, M. F., Ueno, T., Gao, W. Y., Kojima, E., Alcaide, M. L., Chokekijchai, S., Roy, B. M., Arnold, E., & Yarchoan, R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.6.2398 · Cited by 386
Peng, C., Ho, B. K., Chang, T. W., & Chang, N. T. (1989) · Journal of Virology · doi:10.1128/jvi.63.6.2550-2556.1989 · Cited by 371
Pettit, S. C., Moody, M. D., Wehbie, R. S., Kaplan, A. H., Nantermet, P. V., Klein, C. A., & Swanstrom, R. (1994) · Journal of Virology · doi:10.1128/jvi.68.12.8017-8027.1994 · Cited by 355
Metadata
- Authors
- di Marzo Veronese, F., Copeland, T. D., DeVico, A. L., Rahman, R., Oroszlan, S., Gallo, R. C., & Sarngadharan, M. G.
- Venue
- Science
- Published
- 1986-03-14
- Volume
- 231
- Issue
- 4743
- Pages
- 1289-1291
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2011153626
- Cited by
- 545
- References
- 0
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- di Marzo Veronese, F., Copeland, T. D., DeVico, A. L., Rahman, R., Oroszlan, S., Gallo, R. C., & Sarngadharan, M. G. (1986). Characterization of Highly Immunogenic p66/p51 as the Reverse Transcriptase of HTLV-III/LAV. Science. https://doi.org/10.1126/science.2418504
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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