The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity
Open accessAbstract
It is generally believed that the gag gene product of human immunodeficiency virus type 1 (HIV-1) is processed into several core proteins by a virus-specific protease. We used deletion mutation analysis to study the role of HIV-specific protease in the processing of core proteins and its requirement for viral infectivity. Several mutant genomes with deletions in the protease gene were constructed. A mammalian cell line, COS-M6, transfected with the wild-type viral genome was shown to produce virions containing processed core proteins, while COS-M6 cells transfected with two mutated genomes could express only the core protein precursor, Pr56gag. The wild-type transfectant produced infectious virus; both transfectants expressing the mutated genomes also produced virions, and one of them still retained reverse transcriptase activity. However, the mutant viral particles were devoid of infectivity. Virions with a distinct central core and an electron-dense nucleoid budded out from the plasma membrane of COS-M6 cells transfected with the wild-type genome. In contrast, noninfectious virions that budded either into cytoplasmic vacuoles or out from the plasma membrane of COS-M6 cells transfected with mutant genomes contained ring-shaped nucleoids. These results indicate that the HIV-1 protease plays a role not only in the maturation of the core proteins but also in the assembly of the virus and thus is required for viral infectivity.
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Cites
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Self-citationActive human immunodeficiency virus protease is required for viral infectivity
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Metadata
- Authors
- Peng, C., Ho, B. K., Chang, T. W., & Chang, N. T.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1989-06
- Volume
- 63
- Issue
- 6
- Pages
- 2550-2556
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2108612435
- Cited by
- 371
- References
- 38
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Peng, C., Ho, B. K., Chang, T. W., & Chang, N. T. (1989). Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity. Journal of Virology. https://doi.org/10.1128/jvi.63.6.2550-2556.1989
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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