The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mapping the Main Immunogenic Region and Toxin-Binding Site of the Nicotinic Acetylcholine Receptor
Open accessAbstract
The α-chain of the nicotinic acetylcholine receptor carries the binding sites both for cholinergic ligands and for most experimentally induced or naturally occurring antibodies to the native receptor. By means of expression cloning in Escherichia coli , fusion proteins were derived from specific fragments of a complementary DNA encoding the mouse α-chain, allowing the mapping of the toxin-binding site to residues 160-216 and the main immunogenic region to residues 6-85. This approach permits the independent study of different functional domains of a complex receptor molecule and should be generally applicable to other proteins for which complementary DNA clones are available.
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Citations
Cites
Acetylcholine Receptor: An Allosteric Protein
Changeux, J.-P., Devillers-Thiéry, A., & Chemouilli, P. (1984) · Science · doi:10.1126/science.6382611 · Cited by 623
Cited by
Dennis, M., Giraudat, J., Kotzyba-Hibert, F., Goeldner, M., Hirth, C., Chang, J. Y., Lazure, C., Chretien, M., & Changeux, J. P. (1988) · Biochemistry · doi:10.1021/bi00407a016 · Cited by 317
Metadata
- Authors
- Barkas, T., Mauron, A., Roth, B., Alliod, C., Tzartos, S. J., & Ballivet, M.
- Venue
- Science
- Published
- 1987-01-02
- Volume
- 235
- Issue
- 4784
- Pages
- 77-80
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2089337372
- Cited by
- 161
- References
- 1
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- green
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- Barkas, T., Mauron, A., Roth, B., Alliod, C., Tzartos, S. J., & Ballivet, M. (1987). Mapping the Main Immunogenic Region and Toxin-Binding Site of the Nicotinic Acetylcholine Receptor. Science. https://doi.org/10.1126/science.2432658
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