The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Direct Activation of Mammalian Atrial Muscarinic Potassium Channels by GTP Regulatory Protein G k
Abstract
The mammalian heart rate is regulated by the vagus nerve, which acts via muscarinic acetylcholine receptors to cause hyperpolarization of atrial pacemaker cells. The hyperpolarization is produced by the opening of potassium channels and involves an intermediary guanosine triphosphate-binding regulatory (G) protein. Potassium channels in isolated, inside-out patches of membranes from atrial cells now are shown to be activated by a purified pertussis toxin-sensitive G protein of subunit composition αβγ, with an α subunit of 40,000 daltons. Thus, mammalian atrial muscarinic potassium channels are activated directly by a G protein, not indirectly through a cascade of intermediary events. The G protein regulating these channels is identified as a potent G k ; it is active at 0.2 to 1 p M . Thus, proteins other than enzymes can be under control of receptor coupling G proteins.
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Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.
Sternweis, P. C., & Robishaw, J. D. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89817-9 · Cited by 1,301
Calcium tolerant ventricular myocytes prepared by preincubation in a ?KB medium?
Isenberg, G., & Klockner, U. (1982) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/bf00584963 · Cited by 898
GTP-binding proteins couple cardiac muscarinic receptors to a K channel
Pfaffinger, P. J., Martin, J. M., Hunter, D. D., Nathanson, N. M., & Hille, B. (1985) · Nature · doi:10.1038/317536a0 · Cited by 862
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Sakmann, B., Noma, A., & Trautwein, W. (1983) · Nature · doi:10.1038/303250a0 · Cited by 473
Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells
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Cited by
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,539
Diversity and ubiquity of K channels
Rudy, B. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90033-4 · Cited by 1,312
Receptor-effector coupling by G proteins
Birnbaumer, L., Abramowitz, J., & Brown, A. M. (1990) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(90)90007-y · Cited by 1,118
Self-citationG protein involvement in receptor-effector coupling.
Casey, P. J., & Gilman, A. G. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69103-3 · Cited by 608
Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart.
Feldman, A. M., Cates, A. E., Veazey, W. B., Hershberger, R. E., Bristow, M. R., Baughman, K. L., Baumgartner, W. A., & Van Dop, C. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113569 · Cited by 543
Metadata
- Authors
- Yatani, A., Codina, J., Brown, A. M., & Birnbaumer, L.
- Venue
- Science
- Published
- 1987-01-09
- Volume
- 235
- Issue
- 4785
- Pages
- 207-211
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2057951471
- Cited by
- 437
- References
- 19
- FWCI
- 32.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yatani, A., Codina, J., Brown, A. M., & Birnbaumer, L. (1987). Direct Activation of Mammalian Atrial Muscarinic Potassium Channels by GTP Regulatory Protein G k. Science. https://doi.org/10.1126/science.2432660
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
