The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart.
Open accessAbstract
Human heart failure is associated with a diminished contractile response to beta-adrenergic agonists. We hypothesized that alterations in the activity of a guanine nucleotide-binding regulatory protein (G protein) might be partially responsible for this abnormality. We therefore measured the activity of G proteins in failing human myocardium utilizing bacterial toxin-catalyzed ADP ribosylation. The activity of a 40,000-mol wt pertussis toxin substrate (alpha G40) was increased by 36% in failing human hearts when compared with nonfailing controls. In contrast, there was no change in the level of the stimulatory regulatory subunit (Gs). The increased activity in alpha G40 was associated with a 30% decrease in basal as well as 5'-guanylyl imidodiphosphate-stimulated adenylate cyclase activity. These data suggest that increased alpha G40 activity is a new marker for failing myocardium and may account at least in part for the diminished responsiveness to beta 1-adrenergic agonists in the failing human heart.
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Cites
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Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts
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Self-citationIsolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.
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Cited by
Seven-transmembrane-spanning receptors and heart function
Rockman, H. A., Koch, W. J., & Lefkowitz, R. J. (2002) · Nature · doi:10.1038/415206a · Cited by 938
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INTRACELLULAR CALCIUM RELEASE AND CARDIAC DISEASE
Wehrens, X. H. T., Lehnart, S. E., & Marks, A. R. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.114521 · Cited by 355
Diastolic Dysfunction in Congestive Heart Failure
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Metadata
- Authors
- Feldman, A. M., Cates, A. E., Veazey, W. B., Hershberger, R. E., Bristow, M. R., Baughman, K. L., Baumgartner, W. A., & Van Dop, C.
- Venue
- Journal of Clinical Investigation
- Published
- 1988-07-01
- Volume
- 82
- Issue
- 1
- Pages
- 189-197
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2140509492
- Cited by
- 543
- References
- 34
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart. https://app.cochat.ai/papers/10.1172/jci113569
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- Feldman, A. M., Cates, A. E., Veazey, W. B., Hershberger, R. E., Bristow, M. R., Baughman, K. L., Baumgartner, W. A., & Van Dop, C. (1988). Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart. Journal of Clinical Investigation. https://doi.org/10.1172/jci113569
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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