The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-β
Abstract
The role of polypeptide growth factors in the processes of inflammation and repair was investigated by analyzing the influence of transforming growth factor-β (TGF-β), applied directly to linear incisions made through rat dorsal skin. A dose-dependent, direct stimulatory effect of a single application of TGF-β on the breaking strength of healing incisional wounds was demonstrated. An increase in maximum wound strength of 220 percent of control was observed at 5 days; the healing rate was accelerated by approximately 3 days for at least 14 days after production of the wound and application of TGF-β. These increases in wound strength were accompanied by an increased influx of mononuclear cells and fibroblasts and by marked increases in collagen deposition at the site of application of TGF-β. TGF-β is thus a potent pharmacologic agent that can accelerate wound healing in rats.
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Cites
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Cited by
TGF-β signaling and the fibrotic response
Leask, A., & Abraham, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1273rev · Cited by 2,319
Biological Responses to Materials
Anderson, J. M. (2001) · Annual Review of Materials Research · doi:10.1146/annurev.matsci.31.1.81 · Cited by 1,465
TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology
Morikawa, M., Derynck, R., & Miyazono, K. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021873 · Cited by 1,321
Hepatic toxicity resulting from cancer treatment
Lawrence, T. S., Robertson, J. M., Anscher, M. S., Jirtle, R. L., Ensminger, W. D., & Fajardo, L. F. (1995) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(94)00418-k · Cited by 721
Transforming Growth Factor‐β: Major Role in Regulation of Extracellular Matrix
ROBERTS, A. B., HEINE, U. I., FLANDERS, K. C., & SPORN, M. B. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb17931.x · Cited by 696
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Metadata
- Authors
- Mustoe, T. A., Pierce, G. F., Thomason, A., Gramates, P., Sporn, M. B., & Deuel, T. F.
- Venue
- Science
- Published
- 1987-09-11
- Volume
- 237
- Issue
- 4820
- Pages
- 1333-1336
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1983031935
- Cited by
- 941
- References
- 1
- FWCI
- 101.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mustoe, T. A., Pierce, G. F., Thomason, A., Gramates, P., Sporn, M. B., & Deuel, T. F. (1987). Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-β. Science. https://doi.org/10.1126/science.2442813
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
