The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
HIV-1 Reverse Transcriptase Is a Target for Cytotoxic T Lymphocytes in Infected Individuals
Abstract
Characterization of the host immune response to human immunodeficiency virus type 1 (HIV-1) is critical to the rational design of an effective AIDS vaccine. In this study, cytotoxic T lymphocytes (CTL) specific for HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) were found in blood samples from HIV-1-infected individuals. CTL targets were prepared by immortalizing B cells from ten seropositive and six seronegative individuals, and then infecting these cells with recombinant vaccinia viruses containing HIV-1 genes. CTL directed against autologous B lymphoblasts expressing HIV-1 reverse transcriptase were detected in fresh blood samples from eight HIV-1 seropositive subjects, but in no seronegative controls. The effector cells were identified as major histocompatibility complex-restricted CD3+CD8+ lymphocytes. Because the HIV-1 pol gene is highly conserved among different isolates and generates both humoral and cellular immune responses, it bears consideration for inclusion in a candidate AIDS vaccine.
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Starcich, B. R., Hahn, B. H., Shaw, G. M., McNeely, P. D., Modrow, S., Wolf, H., Parks, E. S., Parks, W. P., Josephs, S. F., Gallo, R. C., et al. (1986) · Cell · doi:10.1016/0092-8674(86)90778-6 · Cited by 767
Cited by
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544
Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition
Phillips, R. E., Rowland-Jones, S., Nixon, D. F., Gotch, F. M., Edwards, J. P., Ogunlesi, A. O., Elvin, J. G., Rothbard, J. A., Bangham, C. R. M., Rizza, C. R., et al. (1991) · Nature · doi:10.1038/354453a0 · Cited by 1,015
Nixon, D. F., Townsend, A. R. M., Elvin, J. G., Rizza, C. R., Gallwey, J., & McMichael, A. J. (1988) · Nature · doi:10.1038/336484a0 · Cited by 431
Koenig, S., Conley, A. J., Brewah, Y. A., Jones, G. M., Leath, S., Boots, L. J., Davey, V., Pantaleo, G., Demarest, J. F., Carter, C., et al. (1995) · Nature Medicine · doi:10.1038/nm0495-330 · Cited by 377
Antigenic oscillations and shifting immunodominance in HIV-1 infections
Nowak, M. A., May, R. M., Phillips, R. E., Rowland-Jones, S., Lalloo, D. G., McAdam, S., Klenerman, P., Köppe, B., Sigmund, K., Bangham, C. R. M., et al. (1995) · Nature · doi:10.1038/375606a0 · Cited by 316
Metadata
- Authors
- Walker, B. D., Flexner, C., Paradis, T. J., Fuller, T. C., Hirsch, M. S., Schooley, R. T., & Moss, B.
- Venue
- Science
- Published
- 1988-04
- Volume
- 240
- Issue
- 4848
- Pages
- 64-66
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2038354376
- Cited by
- 267
- References
- 1
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Walker, B. D., Flexner, C., Paradis, T. J., Fuller, T. C., Hirsch, M. S., Schooley, R. T., & Moss, B. (1988). HIV-1 Reverse Transcriptase Is a Target for Cytotoxic T Lymphocytes in Infected Individuals. Science. https://doi.org/10.1126/science.2451288
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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