The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Location and Chemical Synthesis of a Binding Site for HIV-1 on the CD4 Protein
Abstract
The human immunodeficiency virus type 1 (HIV-1) uses the CD4 protein as a receptor for infection of susceptible cells. A candidate structure for the HIV-1 binding site on the CD4 protein was identified by epitope mapping with a family of eight functionally distinct CD4-specific monoclonal antibodies in conjunction with a panel of large CD4-derived synthetic peptides. All of the seven epitopes that were located reside within two immunoglobulin-like disulfide loops situated between residues 1 and 168 of the CD4 protein. The CD4-specific monoclonal antibody OKT4A, a potent inhibitor of HIV-1 binding, recognized a site between residues 32 and 47 on the CD4 protein. By analogy to other members of the immunoglobulin superfamily of proteins, this particular region has been predicted to exist as a protruding loop. A synthetic analog of this loop (residues 25 to 58) showed a concentration-dependent inhibition of HIV-1-induced cell fusion. It is proposed that a loop extending from residues 37 to 53 of the CD4 protein is a binding site for the AIDS virus.
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Citations
Cites
Priming for and induction of anti-poliovirus neutralizing antibodies by synthetic peptides
Emini, E. A., Jameson, B. A., & Wimmer, E. (1983) · Nature · doi:10.1038/304699a0 · Cited by 237
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Cited by
Inhibition of Entry of HIV-1 in Neural Cell Lines by Antibodies Against Galactosyl Ceramide
Harouse, J. M., Bhat, S., Spitalnik, S. L., Laughlin, M., Stefano, K., Silberberg, D. H., & Gonzalez-Scarano, F. (1991) · Science · doi:10.1126/science.1857969 · Cited by 521
Olshevsky, U., Helseth, E., Furman, C., Li, J., Haseltine, W., & Sodroski, J. (1990) · Journal of Virology · doi:10.1128/jvi.64.12.5701-5707.1990 · Cited by 405
Metadata
- Authors
- Jameson, B. A., Rao, P. E., Kong, L. I., Hahn, B. H., Shaw, G. M., Hood, L. E., & Kent, S. B. H.
- Venue
- Science
- Published
- 1988-06-03
- Volume
- 240
- Issue
- 4857
- Pages
- 1335-1339
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2043287597
- Cited by
- 177
- References
- 1
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jameson, B. A., Rao, P. E., Kong, L. I., Hahn, B. H., Shaw, G. M., Hood, L. E., & Kent, S. B. H. (1988). Location and Chemical Synthesis of a Binding Site for HIV-1 on the CD4 Protein. Science. https://doi.org/10.1126/science.2453925
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
