The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding
Open accessAbstract
The binding of the CD4 receptor by the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein is important for virus entry and cytopathic effect. To investigate the CD4-binding region of the gp120 glycoprotein, we altered gp120 amino acids, excluding cysteines, that are conserved among the primate immunodeficiency viruses utilizing the CD4 receptor. Changes in two hydrophobic regions (Thr-257 in conserved region 2 and Trp-427 in conserved region 4) and two hydrophilic regions (Asp-368 and Glu-370 in conserved region 3 and Asp-457 in conserved region 4) resulted in significant reductions in CD4 binding. For most of the mutations affecting these residues, the observed effects on CD4 binding did not apparently result from global conformational disruption of the gp120 molecule, as assessed by measurements of precursor processing, subunit association, and monoclonal antibody recognition. The two hydrophilic regions exhibit a strong propensity for beta-turn formation, are predicted to act as efficient B-cell epitopes, and are located adjacent to hypervariable, glycosylated regions. This study defines a small number of gp120 residues important for CD4 binding, some of which might constitute attractive targets for immunologic intervention.
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Cites
DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
Rapid and efficient site-specific mutagenesis without phenotypic selection.
Kunkel, T. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.2.488 · Cited by 7,206
Barré-Sinoussi, F., Chermann, J. C., Rey, F., Nugeyre, M. T., Chamaret, S., Gruest, J., Dauguet, C., Axler-Blin, C., Vézinet-Brun, F., Rouzioux, C., et al. (1983) · Science · doi:10.1126/science.6189183 · Cited by 7,038
[19] Rapid and efficient site-specific mutagenesis without phenotypic selection
Kunkel, T. A., Roberts, J. D., & Zakour, R. A. (1987) · Methods in Enzymology · doi:10.1016/0076-6879(87)54085-x · Cited by 5,261
Gallo, R. C., Salahuddin, S. Z., Popovic, M., Shearer, G. M., Kaplan, M., Haynes, B. F., Palker, T. J., Redfield, R., Oleske, J., Safai, B., et al. (1984) · Science · doi:10.1126/science.6200936 · Cited by 3,641
Popovic, M., Sarngadharan, M. G., Read, E., & Gallo, R. C. (1984) · Science · doi:10.1126/science.6200935 · Cited by 3,535
The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
Dalgleish, A. G., Beverley, P. C. L., Clapham, P. R., Crawford, D. H., Greaves, M. F., & Weiss, R. A. (1984) · Nature · doi:10.1038/312763a0 · Cited by 3,533
T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV
Klatzmann, D., Champagne, E., Chamaret, S., Gruest, J., Guetard, D., Hercend, T., Gluckman, J.-C., & Montagnier, L. (1984) · Nature · doi:10.1038/312767a0 · Cited by 2,436
Binding of HTLV-III/LAV to T4 + T Cells by a Complex of the 110K Viral Protein and the T4 Molecule
McDougal, J. S., Kennedy, M. S., Sligh, J. M., Cort, S. P., Mawle, A., & Nicholson, J. K. A. (1986) · Science · doi:10.1126/science.3001934 · Cited by 989
Leonard, C. K., Spellman, M. W., Riddle, L., Harris, R. J., Thomas, J. N., & Gregory, T. J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)86956-3 · Cited by 985
Cited by
HADDOCK: A Protein−Protein Docking Approach Based on Biochemical or Biophysical Information
Dominguez, C., Boelens, R., & Bonvin, A. M. J. J. (2003) · Journal of the American Chemical Society · doi:10.1021/ja026939x · Cited by 3,187
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals
Scheid, J. F., Mouquet, H., Feldhahn, N., Seaman, M. S., Velinzon, K., Pietzsch, J., Ott, R. G., Anthony, R. M., Zebroski, H., Hurley, A., et al. (2009) · Nature · doi:10.1038/nature07930 · Cited by 867
Thali, M., Moore, J. P., Furman, C., Charles, M., Ho, D. D., Robinson, J., & Sodroski, J. (1993) · Journal of Virology · doi:10.1128/jvi.67.7.3978-3988.1993 · Cited by 616
Self-citationSelective Transmission of Human Immunodeficiency Virus Type-1 Variants from Mothers to Infants
Wolinsky, S. M., Wike, C. M., Korber, B. T. M., Hutto, C., Parks, W. P., Rosenblum, L. L., Kunstman, K. J., Furtado, M. R., & Muñoz, J. L. (1992) · Science · doi:10.1126/science.1546316 · Cited by 586
Structural biology of HIV 1 1Edited by P. E. Wright
Turner, B. G., & Summers, M. F. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2354 · Cited by 470
Metadata
- Authors
- Olshevsky, U., Helseth, E., Furman, C., Li, J., Haseltine, W., & Sodroski, J.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1990-12
- Volume
- 64
- Issue
- 12
- Pages
- 5701-5707
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1933773138
- Cited by
- 405
- References
- 30
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding. https://app.cochat.ai/papers/10.1128/jvi.64.12.5701-5707.1990
- The paper
- Olshevsky, U., Helseth, E., Furman, C., Li, J., Haseltine, W., & Sodroski, J. (1990). Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding. Journal of Virology. https://doi.org/10.1128/jvi.64.12.5701-5707.1990
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
