The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effect of Forskolin on Voltage-Gated K + Channels Is Independent of Adenylate Cyclase Activation
Abstract
Forskolin is commonly used to stimulate adenylate cyclase in the study of modulation of ion channels and other proteins by adenosine 3′,5′-monophosphate (cAMP)-dependent second messenger systems. In addition to its action on adenylate cyclase, forskolin directly alters the gating of a single class of voltage-dependent potassium channels from a clonal pheochromocytoma (PC12) cell line. This alteration occurred in isolated cell-free patches independent of soluble cytoplasmic enzymes. The effect of forskolin was distinct from those of other agents that raise intracellular cAMP levels. The 1,9-dideoxy derivative of forskolin, which is unable to activate the cyclase, was also effective in altering the potassium channel activity. This direct action of forskolin can lead to misinterpretation of results in experiments in which forskolin is assumed to selectively activate adenylate cyclase.
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Cites
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Cited by
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Sunahara, R. K., Dessauer, C. W., & Gilman, A. G. (1996) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.002333 · Cited by 874
Mediation of Hippocampal Mossy Fiber Long-Term Potentiation by Cyclic AMP
Weisskopf, M. G., Castillo, P. E., Zalutsky, R. A., & Nicoll, R. A. (1994) · Science · doi:10.1126/science.7916482 · Cited by 618
Regulation of neurotransmitter receptor desensitization by protein phosphorylation
Huganir, R. L., & Greengardt, P. (1990) · Neuron · doi:10.1016/0896-6273(90)90211-w · Cited by 440
McCormick, D. A., & Pape, H. C. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018332 · Cited by 422
Regulation of cardiac ion channels by catecholamines, acetylcholine and second messenger systems
Hartzell, H. C. (1988) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(88)90014-4 · Cited by 398
Metadata
- Authors
- Hoshi, T., Garber, S. S., & Aldrich, R. W.
- Venue
- Science
- Published
- 1988-06-17
- Volume
- 240
- Issue
- 4859
- Pages
- 1652-1655
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2069253625
- Cited by
- 268
- References
- 1
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hoshi, T., Garber, S. S., & Aldrich, R. W. (1988). Effect of Forskolin on Voltage-Gated K + Channels Is Independent of Adenylate Cyclase Activation. Science. https://doi.org/10.1126/science.2454506
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
