Mediation of Hippocampal Mossy Fiber Long-Term Potentiation by Cyclic AMP
Abstract
Repetitive activation of hippocampal mossy fibers evokes a long-term potentiation (LTP) of synaptic responses in pyramidal cells in the CA3 region that is independent of N-methyl-D-aspartate receptor activation. Previous results suggest that the site for both the induction and expression of this form of LTP is presynaptic. Experimental elevation of cyclic adenosine 3',5'-monophosphate (cAMP) both mimics and interferes with tetanus-induced mossy fiber LTP, and blockers of the cAMP cascade block mossy fiber LTP. It is proposed that calcium entry into the presynaptic terminal may activate Ca(2+)-calmodulin-sensitive adenylyl cyclase I which, through protein kinase A, causes a persistent enhancement of evoked glutamate release.
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Forskolin, an adenylyl cyclase activator, leads to marked chemical potentiation.
“Similarly, forskolin, an adenylyl cyclase (AC) activator, leads to marked chemical potentiation [29,32,33].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [29]
High-frequency stimulation induces several cAMP-dependent forms of presynaptic plasticity.
“For example, high-frequency stimulation (HFS) induces several cyclic adenosine monophosphate (cAMP)-dependent forms of presynaptic plasticity [21,28–33].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [29]
Forskolin is a widely used adenylyl cyclase activator.
“To maximally activate the cAMP pathway, we applied forskolin, a widely used AC activator [28–31,33,48].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [29]
Because forskolin-induced potentiation occludes with LTP, short-term and long-term plasticity converge on similar pool mechanisms.
“As forskolin-induced potentiation occludes with LTP at this synapse [29], this suggests that both short-term and long-term plasticity converge on similar pool mechanisms.”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [29]
PKA activation is obligatory for the induction and maintenance of mossy fiber LTP.
“Evidence from several laboratories suggests that PKA activation is obligatory for the induction and maintenance of mossy fiber LTP (Y.Y. Huang et al., 1994;Weisskopf et al., 1994).”
From Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation (1998) · cites this paper as Weisskopf et al., 1994
Mossy fiber LTP can be induced by forskolin.
“For example, forskolin evokes LTP at the mossy fiber3 CA3 synapse, whereas the inactive forskolin homolog, 1,9-dideoxy-forskolin, does not (Weisskopf et al., 1994), and mutant mice lacking PKA C1 or Ri subunits are defective in mossy fiber LTP (Huang et al., 1995).”
From Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation (1998) · cites this paper as Weisskopf et al., 1994
Mossy fiber LTP requires PKA activity.
“Evidence from several laboratories suggests that PKA activation is obligatory for the induction and maintenance of mossy fiber LTP (Y.Y. Huang et al., 1994;Weisskopf et al., 1994).”
From Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation (1998) · cites this paper as Weisskopf et al., 1994
Forskolin evokes LTP at the mossy fiber CA3 synapse, whereas the inactive forskolin homolog, 1,9-dideoxy-forskolin, does not.
“For example, forskolin evokes LTP at the mossy fiber3 CA3 synapse, whereas the inactive forskolin homolog, 1,9-dideoxy-forskolin, does not (Weisskopf et al., 1994), and mutant mice lacking PKA C1 or Ri subunits are defective in mossy fiber LTP (Huang et al., 1995).”
From Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation (1998) · cites this paper as Weisskopf et al., 1994
The potentiation caused by forskolin is blocked by inhibitors of PKA.
“The potentiation caused by forskolin is blocked by inhibitors of PK A (Y. Y. Huang et al., 1994;Weisskopf et al., 1994).”
From Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation (1998) · cites this paper as Weisskopf et al., 1994
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- Authors
- Weisskopf, M. G., Castillo, P. E., Zalutsky, R. A., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Science
- Published
- 1994-09-23
- Volume
- 265
- Issue
- 5180
- Pages
- 1878-1882
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2052969380
- Cited by
- 618
- References
- 2
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 18 · 2023: 19 · 2022: 15 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 4 · 2017: 14 · 2016: 8 · 2015: 13 · 2014: 9 · 2013: 14 · 2012: 14
- FWCI
- 15.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- cyclic AMP, hippocampus, CA3 pyramidal cells, protein kinase A, glutamate release, synaptic plasticity
- MeSH terms
- Cyclic AMP, Animals, Calcium, Carbazoles, Colforsin, Glutamates, Guinea Pigs, Hippocampus, Indoles, Isoquinolines, Models, Biological, Nerve Fibers, Synaptic Transmission, Pyrroles, Sulfonamides, Presynaptic Terminals, Long-Term Potentiation, Cyclic AMP-Dependent Protein Kinases, Pyramidal Cells, Glutamic Acid, In Vitro Techniques
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